Inhibitory Effect of CCFM8724 towards - and -Induced Caries in Rats.

is a recognized cariogenic bacterium and a major producer of biofilm matrix. The presence of in dental plaque with . enhances the virulence leading to the onset of rampant caries which is similar to early childhood caries (ECC). The purpose of this study was to explore the effect of CCFM8724 (CCFM8724) on the treatment and prevention of dental caries induced by and . Rats were divided into 6 groups: the control group and model group, 2 treatment groups, and 2 prevention groups (0.02% chlorhexidine or CCFM8724). The fluctuation of microbial colonization and the change of bacteria flora in rat oral cavity after sowing of . CCFM8724 were investigated by colony-forming units (CFU) and microflora analysis. The caries of rats were assessed by microcomputed tomography (micro-CT) and Keyes scoring method. The results showed that CCFM8724 in both the treatment and prevention groups could significantly decrease the population of and in the rats' oral cavity ( < 0.001), the mineral loss of enamel ( < 0.05), and the scores of caries ( < 0.05). Besides, . CCFM8724 exhibited better effects than chlorhexidine. Hence, CCFM8724 was proved to be a potential oral probiotic on caries treatment and prevention and it may have the prospect of application in dental caries (especially ECC) prevention products.