Thompson J L, Bryan M, Bates T, Holmes G L
Department of Neurology and Pediatrics, Medical College of Georgia, Veterans Medical Center, Augusta 30912.
Brain Res. 1988 Jan 1;466(1):149-51. doi: 10.1016/0165-3806(88)90093-4.
In this study, the interaction between electrical kindling and kainic acid seizures was investigated. Prepubescent male rats were kindled using hourly, suprathreshold stimulations. Two days later the kindled rats and their non-kindled controls received systemic injections of either 6, 10, or 17 mg/kg of kainic acid. No differences in response to kainic acid were seen between the two groups. These data demonstrate that the kindled brain does not uniformly exhibit a lower seizure threshold to all convulsants, but is dependent on the agents subsequently used to induce the seizures.
在本研究中，对电点燃与 kainic 酸诱发癫痫之间的相互作用进行了研究。青春期前雄性大鼠通过每小时一次的阈上刺激进行点燃。两天后，点燃的大鼠及其未点燃的对照接受全身注射 6、10 或 17 mg/kg 的 kainic 酸。两组对 kainic 酸的反应未见差异。这些数据表明，点燃的大脑并非对所有惊厥剂都一致地表现出较低的癫痫发作阈值，而是取决于随后用于诱发癫痫发作的药物。
