一个单核苷酸将2019年12月武汉疫情中的新冠病毒与2020年6月中国北京新发地的新冠病毒区分开来。
A single nucleotide distinguishes the SARS-CoV-2 in the Wuhan outbreak in December 2019 from that in Beijing-Xinfadi in June 2020, China.
作者信息
Pan Y-Q, Bahoussi A N, Guo F, Xing L
机构信息
Institute of Biomedical Sciences, Shanxi University, Taiyuan, China.
Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, Shanxi University, Taiyuan, China.
出版信息
New Microbes New Infect. 2020 Dec 15;39:100835. doi: 10.1016/j.nmni.2020.100835. eCollection 2021 Jan.
Two major locally transmitted outbreaks of coronavirus disease 2019 occurred in China, one in Wuhan from December 2019 to April 2020, another in Beijing-Xinfadi in June 2020. Severe acute respiratory syndrome coronavirus 2 isolated from these two outbreaks can be distinguished by a conserved pyrimidine nucleotide located at nucleotide position 241 in the 5'-untranslated region of the virus genome.
2019年冠状病毒病在中国发生了两起主要的本地传播疫情，一起于2019年12月至2020年4月在武汉，另一起于2020年6月在北京新发地。从这两起疫情中分离出的严重急性呼吸综合征冠状病毒2可通过位于病毒基因组5'非翻译区第241位核苷酸处的一个保守嘧啶核苷酸加以区分。
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