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药物发现与早期开发中电有机合成的未来。

The Future of Electro-organic Synthesis in Drug Discovery and Early Development.

作者信息

Stephen H R, Röckl J L

机构信息

Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, United Kingdom.

Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, SE-431 83 Mölndal, Sweden.

出版信息

ACS Org Inorg Au. 2024 Nov 16;4(6):571-578. doi: 10.1021/acsorginorgau.4c00068. eCollection 2024 Dec 4.

DOI:10.1021/acsorginorgau.4c00068
PMID:39649998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11621954/
Abstract

Electro-organic chemistry presents a promising frontier in drug discovery and early development, facilitating novel reactivity aligned with green chemistry principles. Despite this, electrochemistry is not widely used as a synthesis and manufacturing tool in drug discovery or development. This overview seeks to identify key areas that require additional research to make synthetic electrochemistry more accessible to chemists in drug discovery and early development and provide potential solutions. This includes expanding the reaction scope, simplifying rapid scale-up, developing electrode materials, and improving knowledge transfer to aid reproducibility and increase the awareness of electrochemistry. The integration of electro-organic synthesis into drug discovery and development holds the potential to enable efficient, sustainable routes toward future medicines faster than ever.

摘要

电有机化学在药物发现和早期开发领域展现出了一个充满前景的前沿领域，促进了与绿色化学原则相一致的新型反应活性。尽管如此，电化学在药物发现或开发中并未被广泛用作合成和制造工具。本综述旨在确定需要进一步研究的关键领域，以使合成电化学在药物发现和早期开发中更易于化学家使用，并提供潜在的解决方案。这包括扩大反应范围、简化快速放大过程、开发电极材料，以及改善知识转移以有助于重现性并提高对电化学的认识。将电有机合成整合到药物发现和开发中，有可能比以往任何时候都更快地实现通往未来药物的高效、可持续途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/11621954/3582b755cdd9/gg4c00068_0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/11621954/494d9b7b89dc/gg4c00068_0008.jpg
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