Beaman Amanda, Bhide Meera C, McHill Andrew W, Thosar Saurabh S
Oregon Institute of Occupational Health Sciences, Portland, OR, 97239, USA.
Oregon Institute of Occupational Health Sciences, Portland, OR, 97239, USA; School of Nursing, Portland, OR, 97239, USA; Knight Cardiovascular Institute, School of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA; OHSU-PSU School of Public Health, Oregon Health and Science University, Portland, OR 97239, USA.
Sleep Med. 2021 Feb;78:135-140. doi: 10.1016/j.sleep.2020.12.011. Epub 2020 Dec 14.
Cardiovascular disease is the leading cause of death in the world. In addition to non-modifiable factors such as age and sex, cardiovascular risk is also driven by behavioral, and therefore somewhat modifiable, factors such as physical activity, diet, and sleep. It is well established that sleep duration has a U-shaped association with mortality and cardiovascular disease, with recent evidence suggesting that this association is observed even while controlling for the effects of comorbid conditions. Whereas several biological mechanisms mediating the association between chronic short sleep duration and cardiovascular risk have been established, the biological mechanisms underlying the relationship between habitual long sleep (≥9 h) duration and cardiovascular risk, in the absence of other chronic diseases, are not well understood. This review will focus on summarizing the literature investigating the mechanisms underlying the association between habitual long sleep duration and cardiovascular risk. We will also propose the mechanistic pathways, distinct from the ones for short sleep, by which habitual long sleep can increase cardiovascular disease.
心血管疾病是全球主要的死亡原因。除了年龄和性别等不可改变的因素外，心血管风险还受到行为因素的驱动，因此在一定程度上是可以改变的，这些行为因素包括体育活动、饮食和睡眠。众所周知，睡眠时间与死亡率和心血管疾病呈U形关联，最近有证据表明，即使在控制合并症影响的情况下也能观察到这种关联。虽然已经确定了几种介导慢性短睡眠时间与心血管风险之间关联的生物学机制，但在没有其他慢性疾病的情况下，习惯性长睡眠（≥9小时）时间与心血管风险之间关系的潜在生物学机制尚不清楚。本综述将重点总结研究习惯性长睡眠时间与心血管风险之间关联潜在机制的文献。我们还将提出与短睡眠不同的机制途径，通过这些途径，习惯性长睡眠会增加心血管疾病的发生风险。
