Wei Ran, Duan Xiaoye, Guo Lixin
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Peking University Fifth School of Clinical Medicine, Beijing, China.
Korean J Physiol Pharmacol. 2022 Sep 1;26(5):297-305. doi: 10.4196/kjpp.2022.26.5.297.
The presence of artificial light enables humans to be active 24 h a day. Many people across the globe live in a social culture that encourages staying up late to meet the demands of various activities, such as work and school. Sleep deprivation (SD) is a severe health problem in modern society. Meanwhile, as with cardiometabolic disease, there was an obvious tendency that coronary heart disease (CHD) to become a global epidemic chronic disease. Specifically, SD can significantly increase the morbidity and mortality of CHD. However, the underlying mechanisms responsible for the effects of SD on CHD are multilayered and complex. Inflammatory response, lipid metabolism, oxidative stress, and endothelial function all contribute to cardiovascular lesions. In this review, the effects of SD on CHD development are summarized, and SD-related pathogenesis of coronary artery lesions is discussed. In general, early assessment of SD played a vital role in preventing the harmful consequences of CHD.
人造光的存在使人类能够一天24小时保持活动状态。全球许多人生活在一种社会文化中，这种文化鼓励熬夜以满足工作和学习等各种活动的需求。睡眠剥夺（SD）是现代社会中一个严重的健康问题。与此同时，与心脏代谢疾病一样，冠心病（CHD）有明显的成为全球流行性慢性病的趋势。具体而言，睡眠剥夺会显著增加冠心病的发病率和死亡率。然而，睡眠剥夺对冠心病产生影响的潜在机制是多层次且复杂的。炎症反应、脂质代谢、氧化应激和内皮功能都与心血管病变有关。在这篇综述中，总结了睡眠剥夺对冠心病发展的影响，并讨论了与睡眠剥夺相关的冠状动脉病变发病机制。总体而言，早期评估睡眠剥夺对预防冠心病的有害后果起着至关重要的作用。
