Deparment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Department of Psychology and Program in Cognitive Science, University of Arizona, Tucson, AZ, USA.
Trends Cogn Sci. 2021 Mar;25(3):187-199. doi: 10.1016/j.tics.2020.12.007. Epub 2021 Jan 8.
Tracking moment-to-moment change in input and detecting change sufficient to require altering behavior is crucial to survival. Here, we discuss how the brain evaluates change over time, focusing on the hippocampus and its role in tracking context. We leverage the anatomy and physiology of the hippocampal longitudinal axis, re-entrant loops, and amorphous networks to account for stimulus equivalence and the updating of an organism's sense of its context. Place cells have a central role in tracking contextual continuities and discontinuities across multiple scales, a capacity beyond current models of pattern separation and completion. This perspective highlights the critical role of the hippocampus in both spatial cognition and episodic memory: tracking change and detecting boundaries separating one context, or episode, from another.
实时跟踪输入的变化并检测足以改变行为的变化对于生存至关重要。在这里，我们讨论大脑如何随时间评估变化，重点关注海马体及其在跟踪上下文方面的作用。我们利用海马体纵轴、再入环路和非晶网络的解剖和生理学来解释刺激等价性和生物体对其环境的感知的更新。位置细胞在跟踪多个尺度上的上下文连续性和不连续性方面起着核心作用，这种能力超出了当前模式分离和完成的模型。这种观点强调了海马体在空间认知和情景记忆中的关键作用：跟踪变化并检测将一个上下文或情景与另一个上下文或情景分开的边界。
