Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.
Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.
Toxins (Basel). 2021 Jan 9;13(1):46. doi: 10.3390/toxins13010046.
Mycotoxin contamination causes significant economic loss to food and feed industries and seriously threatens human health. Aflatoxins (AFs) are one of the most harmful mycotoxins, which are produced by , , and other fungi that are commonly found in the production and preservation of grain and feed. AFs can cause harm to animal and human health due to their toxic (carcinogenic, teratogenic, and mutagenic) effects. How to remove AF has become a major problem: biological methods cause no contamination, have high specificity, and work at high temperature, affording environmental protection. In the present research, microorganisms with detoxification effects researched in recent years are reviewed, the detoxification mechanism of microbes on AFs, the safety of degrading enzymes and reaction products formed in the degradation process, and the application of microorganisms as detoxification strategies for AFs were investigated. One of the main aims of the work is to provide a reliable reference strategy for biological detoxification of AFs.
真菌毒素污染给食品和饲料工业造成重大经济损失,严重威胁人类健康。黄曲霉毒素(AFs)是最具危害性的真菌毒素之一,由 、 和其他真菌产生,这些真菌在粮食和饲料的生产和保存过程中很常见。由于其毒性(致癌、致畸和致突变)作用,AFs 会对动物和人类健康造成危害。如何去除 AF 已成为一个主要问题:生物方法不会造成污染,具有高度特异性,并在高温下工作,环保。在本研究中,综述了近年来研究的具有解毒作用的微生物,微生物对 AFs 的解毒机制,降解过程中形成的降解酶和反应产物的安全性,以及微生物作为 AFs 解毒策略的应用。这项工作的主要目的之一是为 AFs 的生物解毒提供可靠的参考策略。