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微小RNA在细胞死亡途径中的作用。

The role of microRNAs in cell death pathways.

作者信息

Jang Ji Hoon, Lee Tae-Jin

机构信息

Department of Anatomy, Yeungnam University College of Medicine, Daegu, Korea.

出版信息

Yeungnam Univ J Med. 2021 Apr;38(2):107-117. doi: 10.12701/yujm.2020.00836. Epub 2021 Jan 13.

DOI:10.12701/yujm.2020.00836
PMID:33435638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8016624/
Abstract

MicroRNAs (miRNAs) are a class of noncoding RNAs that negatively regulate target messenger RNAs. In multicellular eukaryotes, numerous miRNAs perform basic cellular functions, including cell proliferation, differentiation, and death. Abnormal expression of miRNAs weakens or modifies various apoptosis pathways, leading to the development of human cancer. Cell death occurs in an active manner that maintains tissue homeostasis and eliminates potentially harmful cells through regulated cell death processes, including apoptosis, autophagic cell death, and necroptosis. In this review, we discuss the involvement of miRNAs in regulating cell death pathways in cancers and the potential therapeutic functions of miRNAs in cancer treatment.

摘要

微小RNA（miRNA）是一类对靶信使RNA起负调控作用的非编码RNA。在多细胞真核生物中，众多miRNA执行基本的细胞功能，包括细胞增殖、分化和死亡。miRNA的异常表达会削弱或改变各种凋亡途径，导致人类癌症的发生。细胞死亡以一种主动的方式发生，通过包括凋亡、自噬性细胞死亡和坏死性凋亡在内的程序性细胞死亡过程维持组织稳态并清除潜在有害细胞。在本综述中，我们讨论了miRNA在调节癌症细胞死亡途径中的作用以及miRNA在癌症治疗中的潜在治疗功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/2c8840765062/yujm-2020-00836f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/c4bb7ae7b721/yujm-2020-00836f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/76bd31cf8079/yujm-2020-00836f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/79f94809de09/yujm-2020-00836f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/2c8840765062/yujm-2020-00836f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/c4bb7ae7b721/yujm-2020-00836f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/76bd31cf8079/yujm-2020-00836f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/79f94809de09/yujm-2020-00836f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/8016624/2c8840765062/yujm-2020-00836f4.jpg

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