Islam Muhammad Torequl, Quispe Cristina, Martorell Miquel, Docea Anca Oana, Salehi Bahare, Calina Daniela, Reiner Željko, Sharifi-Rad Javad
Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Bangladesh.
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Chile.
Int J Vitam Nutr Res. 2022 Jan;92(1):49-66. doi: 10.1024/0300-9831/a000694. Epub 2021 Jan 13.
The novel coronavirus (SARS-CoV-2) causing COVID-19 disease pandemic has infected millions of people and caused more than thousands of deaths in many countries across the world. The number of infected cases is increasing day by day. Unfortunately, we do not have a vaccine and specific treatment for it. Along with the protective measures, respiratory and/or circulatory supports and some antiviral and retroviral drugs have been used against SARS-CoV-2, but there are no more extensive studies proving their efficacy. In this study, the latest publications in the field have been reviewed, focusing on the modulatory effects on the immunity of some natural antiviral dietary supplements, vitamins and minerals. Findings suggest that several dietary supplements, including black seeds, garlic, ginger, cranberry, orange, omega-3 and -6 polyunsaturated fatty acids, vitamins (e.g., A, B vitamins, C, D, E), and minerals (e.g., Cu, Fe, Mg, Mn, Na, Se, Zn) have anti-viral effects. Many of them act against various species of respiratory viruses, including severe acute respiratory syndrome-related coronaviruses. Therefore, dietary supplements, including vitamins and minerals, probiotics as well as individual nutritional behaviour can be used as adjuvant therapy together with antiviral medicines in the management of COVID-19 disease.
导致新冠肺炎疫情大流行的新型冠状病毒（SARS-CoV-2）已在全球许多国家感染了数百万人，并造成数千人死亡。感染病例数量与日俱增。不幸的是，我们尚无针对该病毒的疫苗和特效治疗方法。除采取防护措施外，已采用呼吸和/或循环支持手段以及一些抗病毒和抗逆转录病毒药物来对抗SARS-CoV-2，但尚无更广泛的研究证明其疗效。在本研究中，对该领域的最新出版物进行了综述，重点关注一些天然抗病毒膳食补充剂、维生素和矿物质对免疫力的调节作用。研究结果表明，包括黑种草籽、大蒜、生姜、蔓越莓、橙子、ω-3和ω-6多不饱和脂肪酸、维生素（如维生素A、B族维生素、C、D、E）以及矿物质（如铜、铁、镁、锰、钠、硒、锌）在内的多种膳食补充剂具有抗病毒作用。其中许多对包括严重急性呼吸综合征相关冠状病毒在内的多种呼吸道病毒均有作用。因此，包括维生素、矿物质、益生菌以及个人营养行为在内的膳食补充剂可在新冠肺炎疾病管理中与抗病毒药物一起用作辅助治疗。
