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本文引用的文献

1
Vitamin K epoxide reductase complex subunit 1 (VKORC1) gene polymorphism as determinant of differences in Covid-19-related disease severity.维生素 K 环氧化物还原酶复合物亚基 1(VKORC1)基因多态性作为与 COVID-19 相关疾病严重程度差异的决定因素。
Med Hypotheses. 2020 Nov;144:110218. doi: 10.1016/j.mehy.2020.110218. Epub 2020 Aug 25.
2
Association between regional selenium status and reported outcome of COVID-19 cases in China.中国区域硒状态与新冠病毒疾病病例报告结果之间的关联
Am J Clin Nutr. 2020 Jun 1;111(6):1297-1299. doi: 10.1093/ajcn/nqaa095.
3
Incidence of thrombotic complications in critically ill ICU patients with COVID-19.COVID-19 重症监护病房危重症患者的血栓并发症发生率。
Thromb Res. 2020 Jul;191:145-147. doi: 10.1016/j.thromres.2020.04.013. Epub 2020 Apr 10.
4
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.血管紧张素转换酶2(ACE2)作为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的受体:分子机制与潜在治疗靶点
Intensive Care Med. 2020 Apr;46(4):586-590. doi: 10.1007/s00134-020-05985-9. Epub 2020 Mar 3.
5
Potential interventions for novel coronavirus in China: A systematic review.中国新型冠状病毒潜在干预措施的系统评价。
J Med Virol. 2020 May;92(5):479-490. doi: 10.1002/jmv.25707. Epub 2020 Mar 3.
6
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
7
A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels.一项随机先导试验,旨在评估天然与合成维生素 B 复合物在健康人体中的生物利用度及其对同型半胱氨酸、氧化应激和抗氧化剂水平的影响。
Oxid Med Cell Longev. 2019 Dec 12;2019:6082613. doi: 10.1155/2019/6082613. eCollection 2019.
8
Effect of single-dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo-controlled trial.单次注射维生素D对溃疡性结肠炎患者免疫细胞因子的影响:一项随机安慰剂对照试验
APMIS. 2019 Oct;127(10):681-687. doi: 10.1111/apm.12982. Epub 2019 Jul 26.
9
Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity.膳食和微生物维生素B族在宿主免疫调节中的代谢
Front Nutr. 2019 Apr 17;6:48. doi: 10.3389/fnut.2019.00048. eCollection 2019.
10
Perspective: Should Vitamin E Recommendations for Older Adults Be Increased?观点:是否应该增加老年人维生素 E 的推荐摄入量?
Adv Nutr. 2018 Sep 1;9(5):533-543. doi: 10.1093/advances/nmy035.

维生素和矿物质在 COVID-19 中作为免疫增强剂的作用。

Role of vitamins and minerals as immunity boosters in COVID-19.

机构信息

Department of Pharmacology, Central University of Punjab, Ghudda-151401, Bathinda, Punjab, India.

Department of Pharmacology and Toxicology, University of Genoa, Genoa, Italy.

出版信息

Inflammopharmacology. 2021 Aug;29(4):1001-1016. doi: 10.1007/s10787-021-00826-7. Epub 2021 Jun 10.

DOI:10.1007/s10787-021-00826-7
PMID:34110533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8190991/
Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) known as coronavirus disease (COVID-19), emerged in Wuhan, China, in December 2019. On March 11, 2020, it was declared a global pandemic. As the world grapples with COVID-19 and the paucity of clinically meaningful therapies, attention has been shifted to modalities that may aid in immune system strengthening. Taking into consideration that the COVID-19 infection strongly affects the immune system via multiple inflammatory responses, pharmaceutical companies are working to develop targeted drugs and vaccines against SARS-CoV-2 COVID-19. A balanced nutritional diet may play an essential role in maintaining general wellbeing by controlling chronic infectious diseases. A balanced diet including vitamin A, B, C, D, E, and K, and some micronutrients such as zinc, sodium, potassium, calcium, chloride, and phosphorus may be beneficial in various infectious diseases. This study aimed to discuss and present recent data regarding the role of vitamins and minerals in the treatment of COVID-19. A deficiency of these vitamins and minerals in the plasma concentration may lead to a reduction in the good performance of the immune system, which is one of the constituents that lead to a poor immune state. This is a narrative review concerning the features of the COVID-19 and data related to the usage of vitamins and minerals as preventive measures to decrease the morbidity and mortality rate in patients with COVID-19.

摘要

严重急性呼吸系统综合征冠状病毒 2 型(SARS-CoV-2)又称冠状病毒病(COVID-19),于 2019 年 12 月在中国武汉出现。2020 年 3 月 11 日,它被宣布为全球大流行。随着世界应对 COVID-19 和缺乏具有临床意义的治疗方法,人们的注意力转向了可能有助于增强免疫系统的方法。考虑到 COVID-19 感染通过多种炎症反应强烈影响免疫系统,制药公司正在努力开发针对 SARS-CoV-2 COVID-19 的靶向药物和疫苗。均衡的营养饮食通过控制慢性传染病,可能在维持整体健康方面发挥重要作用。富含维生素 A、B、C、D、E 和 K 以及一些微量元素如锌、钠、钾、钙、氯和磷的均衡饮食可能对各种传染病有益。本研究旨在讨论和介绍维生素和矿物质在治疗 COVID-19 中的作用的最新数据。血浆浓度中这些维生素和矿物质的缺乏可能导致免疫系统的良好性能下降,这是导致免疫状态不佳的因素之一。这是一篇关于 COVID-19 特征和维生素及矿物质使用数据的叙述性综述,作为预防措施,以降低 COVID-19 患者的发病率和死亡率。