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发芽大麦中次生代谢物的变化及其与抗皱活性的关系。

Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity.

机构信息

Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea.

Dermapro Bio Research Center, DERMAPRO Ltd., 213-3 Chumdan-ro, Jeju-si, Jeju-do, 63309, Republic of Korea.

出版信息

Sci Rep. 2021 Jan 12;11(1):758. doi: 10.1038/s41598-020-80322-0.

DOI:10.1038/s41598-020-80322-0
PMID:33436876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7804254/
Abstract

The purpose of this research was to identify metabolite change during barley (Hordeum vulgare) germination and reveal active principles for the anti-wrinkle activity. Barley was germinated with deionized water (DW) and mineral-rich water (MRW) for the comparison of the effect of mineral contents on the metabolites changes during germination. The effects of germinated barley extracts (GBEs) on collagen production and collagenase inhibition were evaluated in vitro using human dermal fibroblasts (HDFs). A pronounced anti-wrinkle activity was observed in the test group treated with the MRW-GBEs. In order to find out the active components related to the anti-wrinkle activity, an orthogonal projection to latent structure-discriminant analysis (OPLS-DA) was performed, using the data from secondary metabolites profiling conducted by UPLC-PDA-ESI-MS. The anti-wrinkle activity of MRW-GBEs was revealed to be associated with the increase of oligomeric compounds of procyanidin and prodelphinidin, indicating that it can be used as an active ingredient for anti-wrinkle agents.

摘要

本研究旨在鉴定大麦（Hordeum vulgare）发芽过程中的代谢物变化，并揭示其抗皱活性的有效成分。大麦分别用去离子水（DW）和富矿水（MRW）进行发芽，以比较矿质含量对发芽过程中代谢物变化的影响。采用人真皮成纤维细胞（HDF）体外实验评估发芽大麦提取物（GBE）对胶原蛋白生成和胶原酶抑制的影响。结果表明，MRW-GBE 处理组表现出显著的抗皱活性。为了找出与抗皱活性相关的有效成分，采用超高效液相色谱-光电二极管阵列-电喷雾质谱联用技术（UPLC-PDA-ESI-MS）进行二次代谢产物分析，通过正交投影到潜在结构判别分析（OPLS-DA）进行数据分析。结果表明，MRW-GBE 的抗皱活性与原花青素和原矢车菊素低聚物化合物的增加有关，表明其可作为抗皱剂的有效成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/1db3b49abf9e/41598_2020_80322_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/2d8c9d5e765d/41598_2020_80322_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/572628564140/41598_2020_80322_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/48216cc3b84d/41598_2020_80322_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/e936a41b4bc5/41598_2020_80322_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/1db3b49abf9e/41598_2020_80322_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/2d8c9d5e765d/41598_2020_80322_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/572628564140/41598_2020_80322_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/48216cc3b84d/41598_2020_80322_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/e936a41b4bc5/41598_2020_80322_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/7804254/1db3b49abf9e/41598_2020_80322_Fig5_HTML.jpg

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2
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J Chromatogr A. 2014 Aug 15;1355:134-42. doi: 10.1016/j.chroma.2014.06.007. Epub 2014 Jun 7.
3
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J Ginseng Res. 2013 Jul;37(3):341-8. doi: 10.5142/jgr.2013.37.341.
4
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Molecules. 2013 Aug 2;18(8):9293-304. doi: 10.3390/molecules18089293.
5
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Molecules. 2012 Oct 1;17(10):11669-79. doi: 10.3390/molecules171011669.
6
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Food Chem. 2012 Dec 1;135(3):950-9. doi: 10.1016/j.foodchem.2012.05.058. Epub 2012 May 23.
7
Metabolite fingerprinting of barley whole seeds, endosperms, and embryos during industrial malting.大麦全种子、胚乳和胚胎在工业制麦过程中的代谢指纹图谱。
J Biotechnol. 2012 Jun 15;159(3):177-87. doi: 10.1016/j.jbiotec.2012.03.012. Epub 2012 Mar 21.
8
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Phytochem Anal. 2012 Sep-Oct;23(5):508-12. doi: 10.1002/pca.2348. Epub 2012 Jan 23.
9
Identification and quantification of flavonoids and phenolic acids in burr parsley (Caucalis platycarpos L.), using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry.采用高效液相色谱-二极管阵列检测和电喷雾电离质谱法对刺芹（Caucalis platycarpos L.）中的黄酮类化合物和酚酸进行鉴定和定量分析。
Molecules. 2009 Jul 9;14(7):2466-90. doi: 10.3390/molecules14072466.
10
Free water-soluble phenolics profiling in barley ( Hordeum vulgare L.).大麦（Hordeum vulgare L.）中游离水溶性酚类物质的分析
J Agric Food Chem. 2009 Mar 25;57(6):2405-9. doi: 10.1021/jf8037727.