Salarolli Roberta T, Alvarenga Livia, Cardozo Ludmila F M F, Teixeira Karla T R, de S G Moreira Laís, Lima Jordana D, Rodrigues Silvia D, Nakao Lia S, Fouque Denis, Mafra Denise
Graduate Program in Nutrition Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil.
Graduate Program in Medical Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil.
Int Urol Nephrol. 2021 Jun;53(6):1231-1238. doi: 10.1007/s11255-020-02760-z. Epub 2021 Jan 12.
Gut dysbiosis is common in patients with chronic kidney disease (CKD) and is closely related to inflammatory processes. Some nutritional strategies, such as bioactive compounds present in curcumin, have been proposed as an option to modulate the gut microbiota and decrease the production of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (pCS) and indole-3 acetic acid (IAA).
To evaluate the effects of curcumin supplementation on uremic toxins plasma levels produced by gut microbiota in patients with CKD on hemodialysis (HD).
Randomized, double-blind trial in 28 patients [53.6 ± 13.4 years, fourteen men, BMI 26.7 ± 3.7 kg/m, dialysis vintage 37.5 (12-193) months]. Fourteen patients were randomly allocated to the curcumin group and received 100 mL of orange juice with 12 g carrot and 2.5 g of turmeric and 14 patients to the control group who received the same juice but without turmeric three times per week after HD sessions for three months. IS, pCS, IAA plasma levels were measured by reverse-phase high-performance liquid chromatography RESULTS: After three months of supplementation, the curcumin group showed a significant decrease in pCS plasma levels [from 32.4 (22.1-45.9) to 25.2 (17.9-37.9) mg/L, p = 0.009], which did not occur in the control group. No statistical difference was observed in IS and IAA levels in both groups.
The oral supplementation of curcumin for three months seems to reduce p-CS plasma levels in HD patients, suggesting a gut microbiota modulation.
肠道菌群失调在慢性肾脏病（CKD）患者中很常见，且与炎症过程密切相关。一些营养策略，如姜黄素中含有的生物活性化合物，已被提议作为调节肠道微生物群和减少尿毒症毒素如硫酸吲哚酚（IS）、对甲酚硫酸盐（pCS）和吲哚 - 3 - 乙酸（IAA）产生的一种选择。
评估补充姜黄素对接受血液透析（HD）的CKD患者肠道微生物群产生的尿毒症毒素血浆水平的影响。
对28例患者进行随机双盲试验[年龄53.6±13.4岁，男性14例，体重指数（BMI）26.7±3.7kg/m²，透析龄37.5（12 - 193）个月]。14例患者随机分配至姜黄素组，每次血液透析后每周3次服用100mL含有12g胡萝卜和2.5g姜黄的橙汁；14例患者分配至对照组，服用不含姜黄的相同果汁。采用反相高效液相色谱法测定IS、pCS、IAA的血浆水平。
补充三个月后，姜黄素组的pCS血浆水平显著降低[从32.4（22.1 - 45.9）降至25.2（17.9 - 37.9）mg/L，p = 0.009]，而对照组未出现这种情况。两组的IS和IAA水平均未观察到统计学差异。
口服姜黄素三个月似乎可降低HD患者的p - CS血浆水平，提示对肠道微生物群有调节作用。
