Sharifi Farrokh, Sooriyarachchi Avinash C, Altural Hayriye, Montazami Reza, Rylander Marissa Nichole, Hashemi Nastaran
Department of Mechanical Engineering, Iowa State University, Ames, Iowa 50011, United States.
Center of Advanced Host Defense Immunobiotics and Translational Medicine, Iowa State University, Ames, Iowa 50011, United States.
ACS Biomater Sci Eng. 2016 Sep 12;2(9):1411-1431. doi: 10.1021/acsbiomaterials.6b00281. Epub 2016 Aug 2.
The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro- and nanofibers for this purpose. The reasons for this growing interest include these materials' high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning, microfluidics, wet spinning, rotary spinning, and self-assembly for drug delivery purposes. Additionally, we discuss the potential to use these fiber based systems in research and clinical applications.
药物递送的目标是确保治疗性分子到达预期的靶器官或组织，从而使药物的有效性最大化。药物递送系统的效率在很大程度上取决于药物载体的选择。最近，人们越来越有兴趣将微纤维和纳米纤维用于这一目的。这种兴趣日益增长的原因包括这些材料的高比表面积、易于制造、高机械性能以及理想的药物释放曲线。在此，我们综述了通过纤维制造的最常用方法（静电纺丝、微流控、湿法纺丝、旋转纺丝和自组装）制备的这些材料在药物递送方面的进展。此外，我们还讨论了在研究和临床应用中使用这些基于纤维的系统的潜力。
