Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, AL 36849, USA.
Clinical Pharmacy Department, College of Pharmacy and Health Sciences, Ajman University, United Arab Emirates.
Neurochem Int. 2021 Mar;144:104958. doi: 10.1016/j.neuint.2021.104958. Epub 2021 Jan 12.
Alzheimer's disease (AD) is the most common neurodegenerative disease, and its incidence is increasing worldwide with increased lifespan. Currently, there is no effective treatment to cure or prevent the progression of AD, which indicates the need to develop novel therapeutic targets and agents. Sirtuins, especially SIRT3, a mitochondrial deacetylase, are NAD-dependent histone deacetylases involved in aging and longevity. Accumulating evidence indicates that SIRT3 dysfunction is strongly associated with pathologies of AD, hence, therapeutic modulation of SIRT3 activity may be a novel application to ameliorate the pathologies of AD. Natural products commonly used in traditional medicine have wide utility and appear to have therapeutic benefits for the treatment of neurodegenerative diseases such as AD. The present review summarizes the currently available natural SIRT3 activators and their potentially neuroprotective molecular mechanisms of action that make them a promising agent in the treatment and management of neurodegenerative diseases such as AD.
阿尔茨海默病（AD）是最常见的神经退行性疾病，随着寿命的延长，其发病率在全球范围内呈上升趋势。目前，尚无有效的治疗方法可以治愈或阻止 AD 的进展，这表明需要开发新的治疗靶点和药物。沉默信息调节因子 2 相关酶 3（SIRT3）是一种依赖烟酰胺腺嘌呤二核苷酸（NAD）的组蛋白去乙酰化酶，主要存在于线粒体中，与衰老和长寿有关。越来越多的证据表明，SIRT3 功能障碍与 AD 的病理学密切相关，因此，调节 SIRT3 活性可能是改善 AD 病理学的一种新方法。传统医学中常用的天然产物具有广泛的用途，并且似乎对治疗 AD 等神经退行性疾病具有治疗益处。本综述总结了目前可用的天然 SIRT3 激活剂及其潜在的神经保护作用机制，使它们成为治疗和管理 AD 等神经退行性疾病的有前途的药物。
