限时进食对肥胖成年人肠道微生物群的影响：一项初步研究。
Effect of time restricted feeding on the gut microbiome in adults with obesity: A pilot study.
作者信息
Gabel Kelsey, Marcell Jarrad, Cares Kate, Kalam Faiza, Cienfuegos Sofia, Ezpeleta Mark, Varady Krista A
机构信息
Department of Kinesiology and Nutrition, University of Illinois at Chicago, USA.
出版信息
Nutr Health. 2020 Jun;26(2):79-85. doi: 10.1177/0260106020910907. Epub 2020 Mar 30.
BACKGROUND
Time restricted feeding is a form of intermittent fasting where participants shorten the daily window in which they eat.
AIM
This is the first study to examine the effects of intermittent fasting on changes in the gut microbiome.
METHODS
Adults with obesity ( = 14) participated in a daily 8-hour time restricted feeding intervention (8-hour feeding window/16-hour fasting window) for 12 weeks. Fecal microbiota were determined by 16 S rRNA (ribosomal ribonucleic acid) gene sequencing of stool samples.
RESULTS
Body weight decreased ( < 0.05) by -2 ± 1 kg. Gut microbiota phylogenetic diversity remained unchanged. The two most common phyla were Firmicutes and Bacteroidetes accounting for 61.2% and 26.9% of total abundance at baseline. No significant alterations in the abundance of Firmicutes, Bacteroidetes, or any other phyla were detected after 12 weeks of time restricted feeding.
CONCLUSIONS
Time restricted feeding did not significantly alter the diversity or overall composition of the gut microbiome.
背景
限时进食是间歇性禁食的一种形式，参与者会缩短每日进食的时间段。
目的
这是第一项研究间歇性禁食对肠道微生物群变化影响的研究。
方法
14名肥胖成年人参与了为期12周的每日8小时限时进食干预（8小时进食窗口/16小时禁食窗口）。通过对粪便样本进行16S rRNA（核糖体核糖核酸）基因测序来确定粪便微生物群。
结果
体重下降了（P<0.05）-2±1千克。肠道微生物群的系统发育多样性保持不变。两个最常见的门是厚壁菌门和拟杆菌门，在基线时分别占总丰度的61.2%和26.9%。限时进食12周后，未检测到厚壁菌门、拟杆菌门或任何其他门的丰度有显著变化。
结论
限时进食并未显著改变肠道微生物群的多样性或总体组成。
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