Fageeh Yahya A, Alnofaie Marwan F, Alhusayni Muhanna A, Aljemyie Ahmed A, Alqurashi Lama S, Alolayani Rayan A, Alaseeri Rayan H, Al-Rasheedi Abdullah N
From the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Saudi Med J. 2025 Aug;46(8):919-925. doi: 10.15537/smj.2025.46.8.20250129.
To assess the prevalence and clinical presentation of laryngopharyngeal reflux (LPR) among adults with chronic tonsillitis and examine how effective reflux treatments are for these patients.
A prospective observational study was conducted at a tertiary referral hospital from March 2024 to January 2025 on adult participants diagnosed with chronic tonsillitis who presented with tonsillar inflammation and sore throat. The participants were evaluated before and after treatment with proton pump inhibitors (PPIs) and dietary and lifestyle modifications for 3 months. The assessment tools used were as follows: visual analog scale (VAS) for sore throat, tonsillar grade, reflux symptom index (RSI), and reflux finding score (RFS).
The study included 112 patients, of whom 81 (72.3%) had LPR based on RSI and RFS measurements. Of the participants who met the criteria for LPR diagnosis, 78 received 3 months of treatment. Of the patients who completed the study treatment protocol, 64.1% reported complete relief from sore throat. Mean VAS scores significantly reduced from 2.69 to 0.97 (<0.001), tonsillar grades from 1.78 to 1.64 (=0.001), RSI scores from 20.6 to 12.7 (<0.001), and RFS scores from 11.1 to 6.40 (<0.001).
This study demonstrates a significant association between chronic tonsillitis and LPR. Treating LPR in patients with chronic tonsillitis with PPIs and dietary and lifestyle modifications can improve LPR and tonsillar inflammation, potentially reducing unnecessary tonsillectomies.
评估慢性扁桃体炎成人患者喉咽反流（LPR）的患病率及临床表现，并探讨反流治疗对这些患者的效果。
2024年3月至2025年1月，在一家三级转诊医院对诊断为慢性扁桃体炎且伴有扁桃体炎症和咽痛的成年参与者进行了一项前瞻性观察研究。参与者在接受质子泵抑制剂（PPI）治疗以及饮食和生活方式调整3个月前后接受评估。使用的评估工具如下：咽痛视觉模拟量表（VAS）、扁桃体分级、反流症状指数（RSI）和反流发现评分（RFS）。
该研究纳入了112名患者，其中根据RSI和RFS测量，81名（72.3%）患有LPR。符合LPR诊断标准的参与者中，78名接受了3个月的治疗。完成研究治疗方案的患者中，64.1%报告咽痛完全缓解。平均VAS评分从2.69显著降至0.97（<0.001），扁桃体分级从1.78降至1.64（=0.001），RSI评分从20.6降至12.7（<0.001），RFS评分从11.1降至6.40（<0.001）。
本研究表明慢性扁桃体炎与LPR之间存在显著关联。用PPI以及饮食和生活方式调整治疗慢性扁桃体炎患者的LPR可改善LPR和扁桃体炎症，可能减少不必要的扁桃体切除术。
