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[儿童养鸟人肺疾病:关于一例罕见且特殊的病例]

[Bird fancier's disease in a child: about a rare and unusual case].

作者信息

Jallouli Abderrahmane, Fakiri Karima El, Rada Noureddine, Draiss Ghizlane, Bouskraoui Mohammed

机构信息

Unité de Pneumopédiatrie, Service de Pédiatrie A, Centre Hospitalier Universitaire Mohammed VI de Marrakech, Marrakech, Maroc.

Faculté de Médecine et de Pharmacie, Université Cadi Ayyad de Marrakech, Marrakech, Maroc.

出版信息

Pan Afr Med J. 2020 Oct 29;37:189. doi: 10.11604/pamj.2020.37.189.26003. eCollection 2020.

Abstract

Bird fancier's disease falls within the spectrum of hypersensitivity pneumonitis secondary to immuno-allergic reaction to avian antigens. This occurs only rarely in children. It is found in two-thirds of patients with hypersensitivity pneumonitis. Diagnosis is not so easy. It is based on a body of clinical evidence. We here report the peculiar case of a 7-year-old girl with a family history of atopic disease initially treated as asthma based on the presence of wheezing and dyspnea and cough without improvement. The patient had worsening of symptoms such as dyspnea at rest complicated by cyanosis in respiratory distress. All of this took place in a context of alteration of general state. Clinical examination showed growth retardation, perioral cyanosis with digital hippocratism. Lung auscultation revealed bilateral crackling sounds. Chest X-ray objectified bilateral interstitial syndrome. Chest computed tomography (CT) scan showed diffuse ground-glass opacities. Laboratory tests revealed hypereosinophilia with hyper-IgE and excluded tuberculosis, cystic fibrosis, immune deficiency. In a second stage interview contact with birds was reported. Serological tests for bird fancier's disease were positive. The patient received inhaled corticosteroids associated with avoidance of exposure to birds. After a follow-up of 2 months, outcome was favorable. Given that the signs of bird fancier's disease are non-specific, this should be suspected in patients with respiratory symptoms associated with exposure to avian antigens.

摘要

养鸟人肺疾病属于对禽类抗原免疫过敏反应继发的超敏性肺炎范畴。这种疾病在儿童中极为罕见。在三分之二的超敏性肺炎患者中可发现此病。诊断并非易事,它基于一系列临床证据。我们在此报告一例特殊病例,一名7岁女孩,有特应性疾病家族史,最初因喘息、呼吸困难和咳嗽被诊断为哮喘,但治疗后未见改善。患者出现如静息时呼吸困难加重并伴有呼吸窘迫时发绀等症状恶化情况。所有这些均发生在全身状况改变的背景下。临床检查显示生长发育迟缓、口周发绀伴杵状指。肺部听诊发现双侧有啰音。胸部X线检查显示双侧间质性综合征。胸部计算机断层扫描(CT)显示弥漫性磨玻璃样混浊。实验室检查显示嗜酸性粒细胞增多伴IgE升高,并排除了结核病、囊性纤维化和免疫缺陷。在第二阶段访谈中,患者报告曾接触鸟类。养鸟人肺疾病的血清学检查呈阳性。患者接受了吸入性糖皮质激素治疗,并避免接触鸟类。经过2个月的随访,结果良好。鉴于养鸟人肺疾病的症状不具有特异性,对于有接触禽类抗原相关呼吸道症状的患者应怀疑此病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03eb/7778181/fbf7a4742ca6/PAMJ-37-189-g001.jpg

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