Soumagne T, Dalphin M L, Dalphin J C
Service de pneumologie, hôpital Jean-Minjoz, CHU de Besançon, 25030 Besançon cedex, France.
Service de pédiatrie, hôpital Jean-Minjoz, CHU de Besançon, 25030 Besançon cedex, France.
Rev Mal Respir. 2019 Apr;36(4):495-507. doi: 10.1016/j.rmr.2018.06.010. Epub 2019 Apr 19.
Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by an immune response to a variety of antigens to which patients have been previously sensitised. It can occur at any age. In children, it is a rare disease, probably under-diagnosed, with an estimated prevalence of 4 per million. The paediatric forms are not really different from those of adults but present some particularities. Avian exposure is by far the most frequent cause of HP, accounting for nearly two-thirds of cases. Although there is no current recommendation for the diagnosis of HP, it is commonly considered that the diagnosis can be made with confidence on the combination of (1) compatible respiratory symptoms, (2) exposure to a known offending antigen, (3) lymphocytic alveolitis, (4) decreased transfer factor for carbon monoxide or hypoxia on exertion and (5) compatible radiologic features. The treatment is based on antigen avoidance that must be complete and definitive. Corticosteroids can be necessary in severe forms. The prognosis of HP in children is better than in adults, with a full clinical and functional recovery in the majority of cases after complete antigenic withdrawal.
过敏性肺炎(HP)是一种间质性肺疾病,由患者先前已致敏的多种抗原引发免疫反应所致。它可发生于任何年龄。在儿童中,这是一种罕见疾病,可能诊断不足,估计患病率为百万分之四。儿童型HP与成人型并无本质区别,但存在一些特点。禽类接触是HP最常见的病因,占近三分之二的病例。尽管目前尚无HP的诊断推荐,但通常认为,结合以下几点可确诊:(1)相符的呼吸道症状;(2)接触已知的致病抗原;(3)淋巴细胞性肺泡炎;(4)一氧化碳转运因子降低或运动时缺氧;(5)相符的放射学特征。治疗基于完全且彻底地避免接触抗原。严重病例可能需要使用皮质类固醇。儿童HP的预后优于成人,在完全撤离抗原后,大多数病例可实现临床和功能的完全恢复。