Safari Narges, Golafshan Nasim, Kharaziha Mahshid, Reza Toroghinejad Mohammad, Utomo Lizette, Malda Jos, Castilho Miguel
Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Department of Orthopedics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
ACS Biomater Sci Eng. 2020 Nov 9;6(11):6253-6262. doi: 10.1021/acsbiomaterials.0c00613. Epub 2020 Oct 16.
Magnesium (Mg)-based alloys are promising biodegradable materials for bone repair applications. However, due to their rapid degradation and high corrosion rate, Mg-based alloys are typically associated with infections and implant failure. This study evaluated the synergistic stability and anti-inflammatory properties that could potentially be achieved by the modification of the Mg alloy with graphene nanoparticles (Gr). Incorporation of low dosages of Gr (0.18 and 0.50 wt %) in a Mg alloy with aluminum (Al, 1 wt %) and copper (Cu, 0.25 wt %) was successfully achieved by a spark plasma sintering (SPS) method. Notably, the degradation rate of the Mg-based alloys was reduced approximately 4-fold and the bactericidal activity was enhanced up to 5-fold with incorporation of only 0.18 wt % Gr to the Mg-1Al-Cu matrix. Moreover, the modified Mg-based nanocomposites with 0.18 wt % Gr demonstrated compressive properties within the range of native cancellous bone (modulus of approximately 6 GPa), whereas studies with human mesenchymal stromal cells (hMSCs) showed high cytocompatibility and superior osteogenic properties compared to non-Gr-modified Mg-1Al-Cu implants. Overall, this study provides foundations for the fabrication of stable, yet fully resorbable, Mg-based bone implants that could reduce implant-associated infections.
镁（Mg）基合金是用于骨修复应用的有前景的可生物降解材料。然而，由于其快速降解和高腐蚀速率，镁基合金通常与感染和植入失败相关。本研究评估了通过用石墨烯纳米颗粒（Gr）改性镁合金可能实现的协同稳定性和抗炎特性。通过放电等离子烧结（SPS）方法成功地在含有铝（Al，1 wt%）和铜（Cu，0.25 wt%）的镁合金中掺入了低剂量的Gr（0.18和0.50 wt%）。值得注意的是，在Mg-1Al-Cu基体中仅掺入0.18 wt%的Gr，镁基合金的降解速率降低了约4倍，杀菌活性提高了5倍。此外，含有0.18 wt% Gr的改性镁基纳米复合材料的压缩性能在天然松质骨范围内（模量约为6 GPa），而用人骨髓间充质基质细胞（hMSCs）进行的研究表明，与未用Gr改性的Mg-1Al-Cu植入物相比，其具有高细胞相容性和优异的成骨特性。总体而言，本研究为制造稳定但可完全吸收的、可减少植入相关感染的镁基骨植入物奠定了基础。
