Wong M L, Highton J, Palmer D G
Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.
Ann Rheum Dis. 1988 Jan;47(1):53-61. doi: 10.1136/ard.47.1.53.
Sequential nailfold capillary microscopy was carried out monthly for seven months in seven patients (four with scleroderma, one with dermatomyositis, one with mixed connective tissue disease, and one with limited connective tissue disease). Progressive enlargement of some capillary loops was observed, with a number becoming obliterated, leaving avascular areas. Extravasation from capillaries usually preceded capillary loss. These observations have shown the progressive nature of the nailfold capillary abnormalities associated with these disorders and suggest that capillary enlargement is the result of injury, rather than compensation for capillary loss.
对7名患者（4例硬皮病、1例皮肌炎、1例混合性结缔组织病和1例局限性结缔组织病）进行了连续7个月的每月一次甲襞毛细血管显微镜检查。观察到一些毛细血管袢逐渐增大，一些毛细血管袢闭塞，形成无血管区。毛细血管渗漏通常先于毛细血管消失。这些观察结果显示了与这些疾病相关的甲襞毛细血管异常的进展性质，并表明毛细血管增大是损伤的结果，而不是对毛细血管消失的代偿。
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