类风湿关节炎患者游离睾酮水平较低。
Low free testosterone levels in rheumatoid arthritis.
作者信息
Spector T D, Perry L A, Tubb G, Silman A J, Huskisson E C
机构信息
Department of Rheumatology and Reproductive Endocrinology, St Bartholomew's Hospital, West Smithfield, London.
出版信息
Ann Rheum Dis. 1988 Jan;47(1):65-8. doi: 10.1136/ard.47.1.65.
Abstract
The androgen status of 25 male patients with rheumatoid arthritis (RA) was assessed and compared with that of age matched controls with osteoarthritis (OA). Significantly reduced levels of serum free testosterone were found in the RA group. Within that group free testosterone was unrelated to all indices of disease activity measured, though it was strongly related to latex positivity. These results support the hypothesis that male sex hormones may have a protective role in RA, though prospective studies would be necessary to determine whether the relation was one of cause or effect.
摘要
对25名类风湿性关节炎（RA）男性患者的雄激素状态进行了评估，并与年龄匹配的骨关节炎（OA）对照者进行了比较。发现RA组血清游离睾酮水平显著降低。在该组中，游离睾酮与所测量的所有疾病活动指标均无关联，尽管它与乳胶阳性密切相关。这些结果支持了男性性激素可能在RA中具有保护作用的假设，不过需要进行前瞻性研究来确定这种关系是因果关系中的哪一种。
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