Department of Pharmacy, University of Reading, Whiteknights, Reading, UK.
Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK.
Colloids Surf B Biointerfaces. 2021 Apr;200:111567. doi: 10.1016/j.colsurfb.2021.111567. Epub 2021 Jan 10.
This review explores the physical, chemical and structural properties of key components of oral care products, whilst looking at the challenges which need to be overcome to continue to improve the efficacy of oral care, and improve dental health. Oral care has been an essential part of all populations and cultures around the world for thousands of years. To maintain good oral health, dental plaque causing bacteria and malodour must be controlled whilst also strengthening and protecting the teeth to prevent dental caries. Advanced modern formulations need to provide controlled and extended release of ingredients vital for dental health. With modern day products such as toothpastes and mouthwashes, it has never been easier to maintain good oral hygiene and health, yet the incidence of dental caries is still on the rise. The complex formulations of modern toothpastes and mouthwashes makes them one of the most sophisticated pharmaceutical products on the market today. The demands of the consumer coupled with the complexity of the oral cavity make it one of the most challenging development processes.
本综述探讨了口腔护理产品关键成分的物理、化学和结构特性，同时研究了为了继续提高口腔护理的功效和改善口腔健康而需要克服的挑战。几千年来，口腔护理一直是世界各地所有人群和文化的重要组成部分。为了保持良好的口腔健康，必须控制导致牙菌斑的细菌和口臭，同时还要增强和保护牙齿以预防龋齿。先进的现代配方需要提供对牙齿健康至关重要的成分的控制和延长释放。有了现代的牙膏和漱口水等产品，保持良好的口腔卫生和健康从未如此简单，但龋齿的发病率仍在上升。现代牙膏和漱口水的复杂配方使其成为当今市场上最复杂的药物产品之一。消费者的需求加上口腔的复杂性使得它成为最具挑战性的开发过程之一。
