Aurup Christian, Kamimura Hermes A S, Konofagou Elisa E
Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Department of Biomedical Engineering, Columbia University, New York, New York, USA; Department of Radiology, Columbia University, New York, New York.
Ultrasound Med Biol. 2021 Apr;47(4):998-1013. doi: 10.1016/j.ultrasmedbio.2020.12.013. Epub 2021 Jan 14.
Ultrasound can modulate activity in the central nervous system, including the induction of motor responses in rodents. Recent studies investigating ultrasound-induced motor movements have described mostly bilateral limb responses, but quantitative evaluations have failed to reveal lateralization or differences in response characteristics between separate limbs or how specific brain targets dictate distinct limb responses. This study uses high-resolution focused ultrasound (FUS) to elicit motor responses in anesthetized mice in vivo and four-limb electromyography (EMG) to evaluate the latency, duration and power of paired motor responses (n = 1768). The results indicate that FUS generates target-specific differences in electromyographic characteristics and that brain targets separated by as little as 1 mm can modulate the responses in individual limbs differentially. Exploiting these differences may provide a tool for quantifying the susceptibility of underlying neural volumes to FUS, understanding the functioning of the targeted neuroanatomy and aiding in mechanistic studies of this non-invasive neuromodulation technique.
超声能够调节中枢神经系统的活动，包括在啮齿动物中诱导运动反应。最近有关超声诱导运动的研究大多描述的是双侧肢体反应，但定量评估未能揭示单独肢体之间的偏侧化或反应特征差异，也未表明特定脑靶点如何决定不同的肢体反应。本研究使用高分辨率聚焦超声（FUS）在体内诱发麻醉小鼠的运动反应，并采用四肢肌电图（EMG）评估配对运动反应的潜伏期、持续时间和功率（n = 1768）。结果表明，FUS会产生特定于靶点的肌电图特征差异，并且相隔仅1毫米的脑靶点就能对各个肢体的反应进行不同的调节。利用这些差异可能提供一种工具，用于量化潜在神经体积对FUS的敏感性，理解靶向神经解剖结构的功能，并有助于对这种非侵入性神经调节技术进行机制研究。
