Wang Yong, Wang Haiying, Yang Fengzhen
The Second Department of Obstetrics, Cangzhou Central Hospital, Yunhe District, Cangzhou, Hebei, China.
Cangzhou Central Hospital, Cangzhou, Hebei, China.
Dose Response. 2020 Dec 29;18(4):1559325820984910. doi: 10.1177/1559325820984910. eCollection 2020 Oct-Dec.
Aloe vera L has been shown to possess hypoglycemic and hypolipidemic effects on type 2 diabetic patients, and its major benefits may be linked to barbaloin, which is a major component of Aloe vera L. This study focused on investigating the potential effects and underlying mechanisms of barbaloin on gestational diabetes mellitus (GDM). The db/+ diabetic mice with GDM were daily orally administered with barbaloin or metformin during the gestational period. The results demonstrated that administration of barbaloin significantly reduced blood glucose levels and increased insulin levels in GDM mice. We further found that barbaloin treatment reduced inflammatory response and ROS levels in the liver. Finally, we revealed that the AMP-activated protein kinase (AMPK) / peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signaling pathway was involved in BAT-mediated beneficial effects on mice with GDM. Our study suggested that barbaloin exerted hypoglycemic and hypolipidemic effects on GDM mice, via, at least in part, modulation of AMPK/ PGC-1α signaling in GDM mice.
已证明库拉索芦荟对2型糖尿病患者具有降血糖和降血脂作用，其主要益处可能与芦荟素有关，芦荟素是库拉索芦荟的主要成分。本研究聚焦于探究芦荟素对妊娠期糖尿病（GDM）的潜在作用及潜在机制。在妊娠期，对患有GDM的db/+糖尿病小鼠每日口服给予芦荟素或二甲双胍。结果表明，给予芦荟素可显著降低GDM小鼠的血糖水平并提高胰岛素水平。我们进一步发现，芦荟素治疗可降低肝脏中的炎症反应和活性氧水平。最后，我们揭示了AMP激活的蛋白激酶（AMPK）/过氧化物酶体增殖物激活受体γ共激活因子1α（PGC-1α）信号通路参与了棕色脂肪组织（BAT）介导的对GDM小鼠的有益作用。我们的研究表明，芦荟素至少部分通过调节GDM小鼠的AMPK/PGC-1α信号通路，对GDM小鼠发挥降血糖和降血脂作用。
