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运动可减轻载脂蛋白E缺乏小鼠的高脂血症诱导的肾损伤。

Exercise reduces hyperlipidemia-induced kidney damage in apolipoprotein E-deficient mice.

作者信息

Qian Chengsi, Yang Qin, Guo Lipeng, Zhu Hupei, You Xi, Liu Hongyang, Sun Yan

机构信息

Department of Cardiology, Zhejiang Province Rongjun Hospital, Jiaxing, Zhejiang 314000, P.R. China.

Department of Internal Medicine, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China.

出版信息

Exp Ther Med. 2021 Feb;21(2):153. doi: 10.3892/etm.2020.9585. Epub 2020 Dec 17.

Abstract

Hyperlipidemia is a risk factor of kidney damage that can lead to chronic kidney disease. Studies have shown that exercise reduces kidney damage; however, the specific mechanisms underlying the protective effects of exercise remain unclear. For 12 weeks, 8-week-old male apolipoprotein E-deficient (ApoE) mice were randomly divided into four treatment groups (n=7/group) as follows: Mice fed a normal diet (ND group); mice fed a ND and exercised (ND + E group); mice fed a high-fat diet (HD group); and mice fed a HD and exercised (HD + E group). Exercise training consisted of swimming for 40 min, 5 days/week. Metabolic parameters, such as low-density lipoprotein-cholesterol, total cholesterol and creatinine levels were higher in the ApoE HD mice compared with those in the ApoE HD + E mice. Serum levels of glutathione peroxidase and superoxide dismutase were significantly decreased in the HD group compared with those in the HD + E group. Significant pathological changes were observed in the HD + E group compared with in the HD group. Immunohistochemistry and immunoblotting revealed increased levels of oxidative stress (nuclear factor erythroid-2-related factor 2) and fibrosis (Smad3 and TGF-β) markers in the ApoE HD group; however, the expression levels of these markers were significantly decreased in the ApoE HD + E group. Furthermore, NF-κB expression in the HD + E group was significantly lower compared with that in the HD group. These results suggested that exercise may exert protective effects against kidney damage caused by hyperlipidemia.

摘要

高脂血症是导致慢性肾病的肾损伤危险因素。研究表明运动可减轻肾损伤;然而,运动产生保护作用的具体机制仍不清楚。将8周龄雄性载脂蛋白E缺陷(ApoE)小鼠随机分为四个治疗组(每组n = 7),持续12周,分组如下:喂食正常饮食的小鼠(ND组);喂食正常饮食并运动的小鼠(ND + E组);喂食高脂饮食的小鼠(HD组);喂食高脂饮食并运动的小鼠(HD + E组)。运动训练包括每周5天、每次40分钟的游泳。与ApoE HD + E小鼠相比,ApoE HD小鼠的代谢参数,如低密度脂蛋白胆固醇、总胆固醇和肌酐水平更高。与HD + E组相比,HD组血清谷胱甘肽过氧化物酶和超氧化物歧化酶水平显著降低。与HD组相比,HD + E组观察到明显的病理变化。免疫组织化学和免疫印迹显示ApoE HD组氧化应激(核因子红细胞2相关因子2)和纤维化(Smad3和TGF-β)标志物水平升高;然而,这些标志物的表达水平在ApoE HD + E组显著降低。此外,与HD组相比,HD + E组中NF-κB表达显著降低。这些结果表明运动可能对高脂血症引起的肾损伤发挥保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29b/7792504/66b7a0baee4b/etm-21-02-09585-g00.jpg

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