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放射治疗中高清多叶准直器的剂量学叶片间距与剂量计算误差之间的关系。

Relationship between dosimetric leaf gap and dose calculation errors for high definition multi-leaf collimators in radiotherapy.

作者信息

Kim Jinkoo, Han James S, Hsia An Ting, Li Shidong, Xu Zhigang, Ryu Samuel

机构信息

Department of Radiation Oncology, Stony Brook University Hospital, Stony Brook, NY, United States.

Department of Radiation Oncology, FoxChase Cancer Center at Temple Hospital, Philadelphia, PA, United States.

出版信息

Phys Imaging Radiat Oncol. 2018 Feb 20;5:31-36. doi: 10.1016/j.phro.2018.01.003. eCollection 2018 Jan.

Abstract

BACKGROUND AND PURPOSE

Dosimetric leaf gap (DLG) is a parameter to model the round-leaf-end effect of multi-leaf collimators (MLC) that is important for treatment planning dose calculations in radiotherapy. In this study we investigated on the relationship between the DLG values and the dose calculation errors for a high-definition MLC.

MATERIALS AND METHODS

Three sets of experiments were conducted: (1) DLG measurements using sweeping-gap technique, (2) DLG adjustment based on spine radiosurgery plan measurements, and (3) DLG verification using films and ion-chambers (IC). All experiments were conducted on a Varian Edge machine equipped with HD120 MLC for 6X, 6XFFF, and 10XFFF (FFF: flattening filter free). The Analytical Anisotropic Algorithm was used for all dose calculations.

RESULTS

The measured physical DLGs were 0.39 mm, 0.27 mm, and 0.42 mm for 6X, 6XFFF, and 10XFFF respectively. The calculated doses were lower by 4.2% (6X), 3.7% (6XFFF), and 6.8% (10XFFF) than the measured, while the adjusted DLG values with minimum errors were 1.1 mm, 0.9 mm, and 1.5 mm. The IC measurement errors were < 1%, and the film gamma pass rates (3%/3 mm) were greater than 97% for the spine plans.

CONCLUSIONS

The calculated doses were systematically lower than measured doses with the physical DLG values. It was necessary to increase the DLG values to minimize the dose calculation uncertainty. The optimal DLG values may be specific to individual MLCs and beams and, thus, careful evaluation and verification are warranted.

摘要

背景与目的

剂量叶片间隙(DLG)是用于模拟多叶准直器(MLC)圆形叶片末端效应的一个参数,对于放射治疗中的治疗计划剂量计算很重要。在本研究中,我们调查了高清MLC的DLG值与剂量计算误差之间的关系。

材料与方法

进行了三组实验:(1)使用扫描间隙技术测量DLG,(2)基于脊柱放射外科计划测量调整DLG,(3)使用胶片和电离室(IC)验证DLG。所有实验均在配备HD120 MLC的瓦里安Edge机器上进行,用于6X、6XFFF和10XFFF(FFF:无 flattening 滤波器)。所有剂量计算均使用解析各向异性算法。

结果

6X、6XFFF和10XFFF的测量物理DLG分别为0.39毫米、0.27毫米和0.42毫米。计算剂量分别比测量剂量低4.2%(6X)、3.7%(6XFFF)和6.8%(10XFFF),而误差最小的调整后DLG值为1.1毫米、0.9毫米和1.5毫米。脊柱计划的IC测量误差<1%,胶片γ通过率(3%/3毫米)大于97%。

结论

使用物理DLG值时,计算剂量系统地低于测量剂量。有必要增加DLG值以最小化剂量计算的不确定性。最佳DLG值可能因单个MLC和射束而异,因此需要进行仔细的评估和验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f20/7807868/e11ed9b543dc/gr1.jpg

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