Su Hui-Fei, Shaker Sharpkate, Kuang Yi, Zhang Meng, Ye Min, Qiao Xue
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University, Beijing, China.
Med Res Rev. 2021 Jul;41(4):1999-2038. doi: 10.1002/med.21785. Epub 2021 Jan 19.
Huang-Qi (Astragali Radix) is an herbal tonic widely used in China and many other countries. It is derived from the roots of Astragalus membranaceus and A. membranaceus var. mongholicus and shows potent cardiovascular protective effects. In this article, we comprehensively reviewed 189 small molecules isolated from the two Astragalus species and discussed the interspecies chemical differences. Moreover, we summarized the pharmacological activities and mechanisms of action of Huang-Qi and its major bioactive compounds for the treatment of cardiovascular diseases. This review covers 171 references published between February 1983 and March 2020.
黄芪是一种在中国和许多其他国家广泛使用的滋补草药。它来源于蒙古黄芪和膜荚黄芪的根，具有强大的心血管保护作用。在本文中，我们全面综述了从这两种黄芪中分离出的189种小分子，并讨论了种间化学差异。此外，我们总结了黄芪及其主要生物活性化合物治疗心血管疾病的药理活性和作用机制。本综述涵盖了1983年2月至2020年3月发表的171篇参考文献。
