Nam Seoung Wan, Kang Taeyoung
Department of Rheumatology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, Korea.
Kang Taeyoung Internal Medicine Clinic, Seoul 04701, Korea.
J Clin Med. 2021 Jan 14;10(2):283. doi: 10.3390/jcm10020283.
The aim of the study was to examine the usefulness of targeted musculoskeletal ultrasonography (MSUS) in assessing the disease activity of patients with early inflammatory arthritis (EIA). Twenty-eight patients with EIA were enrolled. The MSUS examination of joints with arthritic signs (tenderness or swelling), measurement of 28-joint Disease Activity Score (DAS28), and its components were performed at four-week interval visits until power doppler (PD) US remission was achieved. Various MSUS parameters of grey scale (GS) and PD synovitis were measured. Pearson or Spearman correlation coefficients were determined for the purpose of the study. Data were gathered from a total of 85 visits. The Sum of GS grade correlated better with physical examination findings, while the Sum of PD grade correlated better with serum inflammatory markers and patient global health. However, Global OMERACT-EULAR Synovitis Score (GLOESS), which reflected both PD and GS grades, correlated evenly well with each clinical parameter. In addition, GLOESS correlated best with DAS28 in the overall study population ( < 0.01). Conclusively, our targeted MSUS parameters of arthritic joints, especially sums of semi-quantitative grades of synovitis, could be useful in monitoring patients with EIA.
本研究的目的是检验靶向肌肉骨骼超声检查（MSUS）在评估早期炎症性关节炎（EIA）患者疾病活动度方面的效用。纳入了28例EIA患者。对有关节炎体征（压痛或肿胀）的关节进行MSUS检查，每四周随访时测量28关节疾病活动评分（DAS28）及其组成部分，直至功率多普勒（PD）超声检查显示病情缓解。测量了灰阶（GS）和PD滑膜炎的各种MSUS参数。为开展本研究确定了Pearson或Spearman相关系数。共收集了85次随访的数据。GS分级总和与体格检查结果的相关性更好，而PD分级总和与血清炎症标志物及患者整体健康状况的相关性更好。然而，反映PD和GS分级的全球OMERACT-EULAR滑膜炎评分（GLOESS）与各临床参数的相关性均良好。此外，在整个研究人群中，GLOESS与DAS28的相关性最佳（<0.01）。总之，我们针对关节炎关节的MSUS参数，尤其是滑膜炎半定量分级总和，可能有助于监测EIA患者。
