Maugeri Grazia, D'Agata Velia
Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Sciences, University of Catania, 95123 Catania, Italy.
J Funct Morphol Kinesiol. 2020 May 6;5(2):29. doi: 10.3390/jfmk5020029.
Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative disease characterized by the loss of upper and lower motor neurons. To date, no resolutive cure is available, and only two Food and Drug Administration-approved drugs are used to treat ALS without a resolutive outcome. In recent years, the study of the beneficial effects of physical activity on health has acquired special relevance. However, the relationship between ALS progression and physical exercise is still a hotly debated topic in medicine. Some studies have suggested higher risks to develop the disease that are associated with practicing intense physical activity, as seen in professional soccer or football players, for example. On the contrary, moderate training has been shown to exert several benefits in ALS-affected patients. Overall, more studies are needed to clarify whether physical activity is helpful or harmful for developing ALS.
肌萎缩侧索硬化症（ALS）是一种异质性神经退行性疾病，其特征是上下运动神经元丧失。迄今为止，尚无根治方法，仅有两种经美国食品药品监督管理局批准的药物用于治疗ALS，但均未取得根治效果。近年来，体育活动对健康有益影响的研究具有特殊意义。然而，ALS进展与体育锻炼之间的关系仍是医学上一个备受争议的话题。一些研究表明，从事高强度体育活动（如职业足球运动员）会增加患该病的风险。相反，适度训练已被证明对ALS患者有诸多益处。总体而言，需要更多研究来阐明体育活动对ALS的发展是有益还是有害。
