Hong Yu-Han, Hung Kuang-Chen, Lin Chih-Li, Hung Chia-Lien, Tu Shih-Kai, Yang Deng-Ho, Liao Chun-Cheng
Department of Family Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan.
Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Diabetes Metab Syndr Obes. 2025 Jun 18;18:1977-1984. doi: 10.2147/DMSO.S483344. eCollection 2025.
This study examined the association between specific combinations of metabolic syndrome (MS) components and the risk of hypogonadism in Taiwanese men.
We retrospectively analyzed 6,986 men who underwent health screening from 2009 to 2017. MS was defined as meeting at least three of five criteria: waist circumference (W), triglycerides (T), high-density lipoprotein cholesterol (H), fasting glucose (F), and blood pressure (B). Hypogonadism was defined as total testosterone <300 ng/dL. Differences in MS component prevalence between men with and without hypogonadism were compared. Logistic regression adjusted for age and body mass index was used to assess associations.
Among all participants, 6,221 (89.0%) had hypogonadism. The prevalence of MS components was significantly higher in this group (p < 0.001). The risk of hypogonadism increased with the number of MS compon ents. Notably, the combinations F-H-W, F-H-B-W, and F-T-H-B-W were associated with significantly higher odds of hypogonadism.
Specific MS component combinations are strongly associated with increased hypogonadism risk in Taiwanese men. These findings suggest that MS composition, not just its presence, should be considered in evaluating testosterone deficiency.
本研究探讨台湾男性代谢综合征（MS）各组分的特定组合与性腺功能减退风险之间的关联。
我们回顾性分析了2009年至2017年期间接受健康筛查的6986名男性。MS被定义为符合五项标准中的至少三项：腰围（W）、甘油三酯（T）、高密度脂蛋白胆固醇（H）、空腹血糖（F）和血压（B）。性腺功能减退被定义为总睾酮<300 ng/dL。比较了有和没有性腺功能减退的男性之间MS组分患病率的差异。使用经年龄和体重指数调整的逻辑回归来评估关联。
在所有参与者中，6221人（89.0%）患有性腺功能减退。该组中MS组分的患病率显著更高（p<0.001）。性腺功能减退的风险随着MS组分数量的增加而增加。值得注意的是，F-H-W、F-H-B-W和F-T-H-B-W组合与性腺功能减退的显著更高几率相关。
特定的MS组分组合与台湾男性性腺功能减退风险增加密切相关。这些发现表明，在评估睾酮缺乏时，应考虑MS的组成，而不仅仅是其存在情况。
