Washington University School of Medicine, 600 S Taylor Ave, Ste 102, St Louis, MO 63110. Email:
Am J Manag Care. 2021 Jan 1;27(1):e7-e15. doi: 10.37765/ajmc.2021.88578.
Palliative care has been demonstrated to have positive effects for patients, families, health care providers, and health systems. Early identification of patients who are likely to benefit from palliative care would increase opportunities to provide these services to those most in need. This study predicted all-cause mortality of patients as a surrogate for patients who could benefit from palliative care.
Claims and electronic health record (EHR) data for 59,639 patients from a large integrated health care system were utilized.
A deep learning algorithm-a long short-term memory (LSTM) model-was compared with other machine learning models: deep neural networks, random forest, and logistic regression. We conducted prediction analyses using combined claims data and EHR data, only claims data, and only EHR data, respectively. In each case, the data were randomly split into training (80%), validation (10%), and testing (10%) data sets. The models with different hyperparameters were trained using the training data, and the model with the best performance on the validation data was selected as the final model. The testing data were used to provide an unbiased performance evaluation of the final model.
In all modeling scenarios, LSTM models outperformed the other 3 models, and using combined claims and EHR data yielded the best performance.
LSTM models can effectively predict mortality by using a combination of EHR data and administrative claims data. The model could be used as a promising clinical tool to aid clinicians in early identification of appropriate patients for palliative care consultations.
姑息治疗已被证明对患者、家属、医疗保健提供者和医疗系统具有积极影响。早期识别可能从姑息治疗中受益的患者将增加向最需要的人提供这些服务的机会。本研究通过预测患者的全因死亡率,来预测哪些患者可能受益于姑息治疗。
利用来自大型综合医疗保健系统的 59639 名患者的索赔和电子健康记录 (EHR) 数据。
一种深度学习算法——长短期记忆 (LSTM) 模型——与其他机器学习模型(深度神经网络、随机森林和逻辑回归)进行了比较。我们分别使用合并的索赔数据和 EHR 数据、仅索赔数据和仅 EHR 数据进行预测分析。在每种情况下,数据都随机分为训练(80%)、验证(10%)和测试(10%)数据集。使用训练数据训练不同超参数的模型,并选择验证数据性能最佳的模型作为最终模型。使用测试数据对最终模型进行无偏性能评估。
在所有建模场景中,LSTM 模型均优于其他 3 种模型,且使用合并的索赔和 EHR 数据可获得最佳性能。
LSTM 模型可以通过结合 EHR 数据和管理索赔数据有效预测死亡率。该模型可作为一种有前途的临床工具,帮助临床医生早期识别适合姑息治疗咨询的患者。