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抑制宫颈癌的有效天然化合物。

The effective natural compounds for inhibiting Cervical cancer.

机构信息

Education Faculty, Department of Mathematics and Science Education, Science Education, Kırıkkale University, Yahşihan, 71450, Kırıkkale, Turkey.

出版信息

Med Oncol. 2021 Jan 20;38(2):12. doi: 10.1007/s12032-021-01456-3.

Abstract

The secondary compounds found in plants are of great importance in the treatment of many diseases in medicine and pharmacy. Some of these compounds have been reported to exhibit anticarcinogenic effects by inhibiting the growth and metastatic potential of cancer cells. Consumption of the required amount of vegetables and fruits appears to have a protective effect of these secondary compounds on cancer, since most of these drugs are synthesized from natural or natural origin compounds. Secondary compounds in medicinal plants have been found to have an antiproliferative effect by increasing the expression of p53 in cervical cancer cells and decreasing the expression of cyclin D1, one of the cell proliferation markers. The most important step in the fight against cancer is the development of drugs that are selectively targeted against tumor cells and targeting cancer cells to reduce damage to normal cells and prevent the growth and spread of cancer cells. Molecular insertion test is an effective tool for evaluating the bioactivity of possible molecules. In this study, the effect of natural compounds in some medicinal plants in inhibiting cervical cancer, the points where they are effective using docking has been investigated.

摘要

植物中的次生化合物在医学和药学治疗许多疾病方面具有重要意义。一些研究表明,这些化合物通过抑制癌细胞的生长和转移潜力,具有抗癌作用。摄入足够的蔬菜和水果似乎对这些次生化合物具有保护癌症的作用,因为这些药物中的大多数都是从天然或天然来源的化合物合成而来。研究发现,药用植物中的次生化合物通过增加宫颈癌细胞中 p53 的表达和降低细胞增殖标志物之一 cyclin D1 的表达,具有抗增殖作用。抗癌斗争的最重要步骤是开发针对肿瘤细胞的选择性靶向药物,并靶向癌细胞以减少对正常细胞的损伤,防止癌细胞的生长和扩散。分子插入试验是评估可能的分子生物活性的有效工具。在这项研究中,研究了一些药用植物中的天然化合物在抑制宫颈癌方面的作用,以及使用对接研究它们在哪些有效点发挥作用。

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