Department of Mathematics and Science Education, Science Education, Education Faculty, Kırıkkale University, Yahşihan, 71450, Kırıkkale, Turkey.
Med Oncol. 2022 Jun 8;39(8):115. doi: 10.1007/s12032-022-01704-0.
The extracts obtained from plants have been used in the treatment of many diseases since the earliest times. Today, it is of great importance to investigate the effects of the active molecules in these plant extracts at the molecular level together with the analysis. The effect of certain active compounds found in some plants, widely used as medicinal plants, on breast cancer has been investigated using docking. As a result of the docking scores obtained, it can be understood that the active molecules used in this study can be quite effective in controlling breast cancer. Promyelocytic leukemia is an important checkpoint from the literature for breast cancer and the docking energy values of Thymoquinone, Piperine and Carvacrol, as the active molecules in the control of this pathway. This study is very important when evaluated in terms of directing experimental studies by determining the most suitable active substances by comparing the activities of molecules in a short time.
从最早的时候起，从植物中提取的物质就被用于治疗许多疾病。今天，从分子水平上研究这些植物提取物中的活性分子的作用以及分析它们的作用非常重要。使用对接研究了一些被广泛用作药用植物的植物中某些活性化合物对乳腺癌的影响。根据对接得到的分数，可以理解的是，在这项研究中使用的活性分子在控制乳腺癌方面可能非常有效。早幼粒细胞白血病是乳腺癌的一个重要的检查点，而 Thymoquinone、Piperine 和 Carvacrol 的对接能量值，作为控制该途径的活性分子。通过比较分子的活性，在短时间内确定最合适的活性物质，通过比较分子的活性来指导实验研究，这项研究具有重要意义。
