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后封锁时期通过快速周期性切换来抑制 COVID-19。

Post-lockdown abatement of COVID-19 by fast periodic switching.

机构信息

Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom.

Dyson School of Design Engineering, Imperial College London, London, United Kingdom.

出版信息

PLoS Comput Biol. 2021 Jan 21;17(1):e1008604. doi: 10.1371/journal.pcbi.1008604. eCollection 2021 Jan.

Abstract

COVID-19 abatement strategies have risks and uncertainties which could lead to repeating waves of infection. We show-as proof of concept grounded on rigorous mathematical evidence-that periodic, high-frequency alternation of into, and out-of, lockdown effectively mitigates second-wave effects, while allowing continued, albeit reduced, economic activity. Periodicity confers (i) predictability, which is essential for economic sustainability, and (ii) robustness, since lockdown periods are not activated by uncertain measurements over short time scales. In turn-while not eliminating the virus-this fast switching policy is sustainable over time, and it mitigates the infection until a vaccine or treatment becomes available, while alleviating the social costs associated with long lockdowns. Typically, the policy might be in the form of 1-day of work followed by 6-days of lockdown every week (or perhaps 2 days working, 5 days off) and it can be modified at a slow-rate based on measurements filtered over longer time scales. Our results highlight the potential efficacy of high frequency switching interventions in post lockdown mitigation. All code is available on Github at https://github.com/V4p1d/FPSP_Covid19. A software tool has also been developed so that interested parties can explore the proof-of-concept system.

摘要

新冠病毒防治策略存在风险和不确定性,可能导致感染的反复出现。 我们以严格的数学证据为基础,证明了周期性、高频次的封锁与解封交替可以有效减轻第二波疫情的影响,同时保持(尽管减少)经济活动。周期性带来了(i)可预测性,这对经济可持续性至关重要,以及(ii)稳健性,因为封锁期不会因短期的不确定测量而激活。反过来,虽然不能消灭病毒,但这种快速切换策略可以随着时间的推移持续实施,它可以减轻感染,直到疫苗或治疗方法出现,同时减轻与长期封锁相关的社会成本。通常,这种政策可能是每周工作 1 天,封锁 6 天(或者可能是工作 2 天,休息 5 天),并可以根据较长时间尺度上的过滤测量结果以较慢的速度进行修改。我们的研究结果强调了高频切换干预措施在后封锁缓解中的潜在效果。所有代码都可以在 Github 上获得,网址为 https://github.com/V4p1d/FPSP_Covid19。还开发了一个软件工具,以便感兴趣的各方可以探索该概念验证系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee3/7861565/d08eee5bc288/pcbi.1008604.g001.jpg

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