Sakthi Mohan Priyadarshini, Sonsuddin Faridah, Mainal Azizah Binti, Yahya Rosiyah, Venkatraman Gopinath, Vadivelu Jamuna, Al-Farraj Dunia A, Al-Mohaimeed Amal M, Alarijani Khaloud Mohammed
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
Centre for Foundation Studies in Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
Antibiotics (Basel). 2021 Jan 18;10(1):86. doi: 10.3390/antibiotics10010086.
This paper presents for the first time a successful fabrication of ternary ZnO/TiO/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO) and silver (Ag) nanoparticles (NPs) synthesised using fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO and Ag were introduced into the precursor solutions under microwave irradiation to obtain ZnO/TiO/Ag nanocomposites (NCs). This material demonstrated enhanced bactericidal effect towards bacterial pathogens compared to that of the binary TiO/Ag, Ag and TiO alone. In vitro cytotoxicity results of the as-synthesised ZnO/TiO/AgNCs on RAW 264.7 macrophages and A549 cell lines revealed a negative role in cytotoxicity, but contributed astoundingly towards antimicrobials as compared of Ag alone and binary Ag/TiO. This study shows that the resultant ternary metal/bi-semiconductor nanocomposites may provide a therapeutic strategy for the eradication of bacterial pathogens without affecting the healthy mammalian cells.
本文首次成功制备了由氧化锌（ZnO）、二氧化钛（TiO）和银（Ag）纳米颗粒（NPs）组成的三元ZnO/TiO/Ag纳米复合材料，这些纳米颗粒是利用水果（MCF）提取物合成的。采用共沉淀法合成ZnONPs，并在微波辐射下将TiO和Ag引入前驱体溶液中，以获得ZnO/TiO/Ag纳米复合材料（NCs）。与二元TiO/Ag、单独的Ag和TiO相比，这种材料对细菌病原体表现出增强的杀菌效果。合成的ZnO/TiO/AgNCs对RAW 264.7巨噬细胞和A549细胞系的体外细胞毒性结果显示，其在细胞毒性方面起负面作用，但与单独的Ag和二元Ag/TiO相比，在抗菌方面有惊人的作用。这项研究表明，所得的三元金属/生物半导体纳米复合材料可能为根除细菌病原体提供一种治疗策略，而不影响健康的哺乳动物细胞。
