RNA Therapeutics Program, Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA.
Cells. 2021 Jan 19;10(1):187. doi: 10.3390/cells10010187.
mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target "undruggable" diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.
mRNA 在全球呼吁开发 COVID-19 疗法的过程中成为一种重要的生物分子。合成的体外转录 (IVT) mRNA 可以被设计成模拟天然存在的 mRNA，并可用作靶向“不可成药”疾病的工具。RNA 治疗学领域的最新进展解决了这种药物分子所固有的挑战，这种方法现在正被应用于几种治疗方式，从癌症免疫疗法到疫苗开发。在这篇综述中，我们讨论了使用 mRNA 来生成或增强干细胞，以达到心血管再生的目的。
