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汉坦病毒:我们正在等待的下一次大流行?

Hantavirus: The Next Pandemic We Are Waiting For?

机构信息

Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.

The CAS Key Laboratory of Innate Immunity and Chronic Diseases, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China (USTC), Collaborative Innovation Center of Genetics and Development, Hefei, 230027, P.R. China.

出版信息

Interdiscip Sci. 2021 Mar;13(1):147-152. doi: 10.1007/s12539-020-00413-4. Epub 2021 Jan 24.

Abstract

Hantaviruses, albeit reported more than 40 years ago, are now considered emerging viruses' because of their growing importance as human pathogens. Hantavirus created focal news when the paradoxical spread was reported during the world's pandemic battle of the COVID-19, killing a man in Yunnan province of China, further jeopardizing the existing of the human race on the planet earth. In recent years an increasing number of infections and human-to-human transmission is creating a distressing situation. In this short communication, we have focused on the biology, pathogenesis, immunology, epidemiology and future perspective of the Hantaviruses. Our understandings of hantavirus related pandemics and syndrome are limited, the contributing environmental factors, the cellular and viral dynamics in transmission from natural reservoirs to humans and finally, the virology in humans is quite intricate. Priorities for future research suggest that setting up scientific collaboration, the funding, and encouragement of health ministries and the research institutes should take admirable steps to build an understanding of this virus. Discovering new drugs or other therapeutic molecules such as vaccines takes a longer time. Thus with the recent artificial intelligence (AI) technology, the rifle for impending new medicines should be hastened. Last but not least, a data-sharing platform should be provided where all the researchers should share and make available all the necessary information such as genomics, proteomics, host-factors, and other epigenetics information, which will encourage the research collaboration in the preparation against the Hantaviruses.

摘要

汉坦病毒虽然早在 40 多年前就有报道,但由于其作为人类病原体的重要性日益增加,现在被认为是新兴病毒。当 COVID-19 大流行期间报告了反常传播时,汉坦病毒引起了轰动,中国云南省的一名男子因此死亡,这进一步危及了地球上人类的生存。近年来,越来越多的感染和人际传播造成了令人痛苦的局面。在这篇简短的交流中,我们重点介绍了汉坦病毒的生物学、发病机制、免疫学、流行病学和未来展望。我们对汉坦病毒相关大流行和综合征的了解有限,环境因素的促成作用,从自然宿主传播到人类的细胞和病毒动态,最后,人类的病毒学非常复杂。未来研究的重点表明,应建立科学合作,提供资金,并鼓励卫生部和研究所采取令人钦佩的步骤来建立对这种病毒的理解。发现新的药物或其他治疗分子,如疫苗,需要更长的时间。因此,利用最近的人工智能(AI)技术,应该加快寻找即将出现的新药的速度。最后但同样重要的是,应该提供一个数据共享平台,所有研究人员都应该在该平台上共享和提供所有必要的信息,如基因组学、蛋白质组学、宿主因素和其他表观遗传学信息,这将鼓励针对汉坦病毒的研究合作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdec/7826498/5c2ff2bd7be2/12539_2020_413_Fig1_HTML.jpg

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