Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Vector Borne Zoonotic Dis. 2011 Nov;11(11):1459-64. doi: 10.1089/vbz.2010.0255. Epub 2011 Jul 14.
Hantaviruses are distributed throughout the United States and are the etiologic agents for hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. Hantavirus genotypes and epidemiologic patterns vary spatially across the United States. While several longitudinal studies have been performed in the western United States, little is known about the virus in the eastern United States. We undertook a longitudinal study of hantaviruses in the primary rodent reservoir host in central Pennsylvania, Peromyscus leucopus. Prevalence of hantavirus antibodies varied both by year and site, but was not correlated with host abundance. Males were significantly more likely to have antibodies to a hantavirus than females, and both antibody sero-conversion and antibody prevalence increased with mass class (indicator for age). Our findings suggest that one or more hantaviruses are present and circulating among P. leucopus of central Pennsylvania, and understanding the dynamics in this region could help prevent zoonotic transmission to humans. Our aim was to describe the differences in epizootiology of hantavirus infection in rodents from various geographical locations to enable improved analysis of the risk of rodent-to-human transmission and obtain insights that may indicate improved means of disease intervention.
汉坦病毒分布于美国各地，是汉坦病毒肺综合征和肾综合征出血热的病原体。汉坦病毒基因型和流行病学模式在美国各地的空间上存在差异。虽然在美国西部进行了几项纵向研究，但对美国东部的病毒知之甚少。我们在宾夕法尼亚州中部的主要啮齿动物储存宿主白足鼠（Peromyscus leucopus）中进行了汉坦病毒的纵向研究。汉坦病毒抗体的流行率因年份和地点而异，但与宿主丰度无关。雄性比雌性更有可能对汉坦病毒产生抗体，抗体血清转化率和抗体流行率随着体重等级（年龄指标）的增加而增加。我们的研究结果表明，一种或多种汉坦病毒存在于宾夕法尼亚州中部的白足鼠中，并在循环中传播，了解该地区的动态可能有助于防止人畜间的 zoonotic 传播。我们的目的是描述不同地理位置啮齿动物中汉坦病毒感染的流行情况的差异，以便能够更好地分析啮齿动物向人类传播的风险，并获得可能表明改进疾病干预措施的见解。
