益生菌对糖尿病肾病氧化应激和炎症状态的影响：一项临床试验的系统评价和荟萃分析
Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials.
作者信息
Bohlouli Jalal, Namjoo Iman, Borzoo-Isfahani Mohammad, Hojjati Kermani Mohammad Ali, Balouch Zehi Zakiyeh, Moravejolahkami Amir Reza
机构信息
Department of Nutrition, Nutrition and Food Security Research Centre, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Heliyon. 2021 Jan 10;7(1):e05925. doi: 10.1016/j.heliyon.2021.e05925. eCollection 2021 Jan.
This systematic review and meta-analysis was performed to evaluate the effect of probiotics on serum high sensitivity-C reactive protein (hs-CRP) and oxidative stress biomarkers among patients with Diabetic Nephropathy (DN). Electronic databases were searched through May 10, 2020. Seven trials that included 340 patients were identified for analysis. Meta-analysis indicated that probiotics significantly reduced hs-CRP (WMD = -1.53 mg/L; 95% CI = -2.38, -0.69; P < 0.001) and Malondialdehyde (MDA) (WMD = -0.62 ɥmol/L; 95% CI = -1.18, -0.06; P = 0.030) levels in DN patients, whereas they increased Glutathione (GSH) (WMD = 73.84 ɥmol/L; 95% CI = 24.3, 123.29; P = 0.003) and Total Antioxidant Capacity (TAC) (WMD = 26.54 mmol/L; 95% CI = 6.23, 46.85; P = 0.010). Therefore, probiotics may improve hs-CRP and oxidative stress biomarkers in DN population.
本系统评价和荟萃分析旨在评估益生菌对糖尿病肾病（DN）患者血清高敏C反应蛋白（hs-CRP）和氧化应激生物标志物的影响。检索电子数据库至2020年5月10日。共纳入7项试验，340例患者进行分析。荟萃分析表明，益生菌可显著降低DN患者的hs-CRP（加权均数差[WMD]=-1.53mg/L；95%可信区间[CI]=-2.38，-0.69；P<0.001）和丙二醛（MDA）水平（WMD=-0.62μmol/L；95%CI=-1.18，-0.06；P=0.030），同时提高谷胱甘肽（GSH）水平（WMD=73.84μmol/L；95%CI=24.3，123.29；P=0.003）和总抗氧化能力（TAC）（WMD=26.54mmol/L；95%CI=6.23，46.85；P=0.010）。因此，益生菌可能改善DN人群的hs-CRP和氧化应激生物标志物水平。
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