Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Radiology and Medical Imaging Center, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dermatol Ther. 2021 Mar;34(2):e14803. doi: 10.1111/dth.14803. Epub 2021 Feb 8.
Inflammatory and autoimmune skin diseases such as vitiligo may be associated with systemic disorders, including endocrine and cardiovascular diseases, due to some similarities in the pathogenesis. It was aimed to evaluate metabolic syndrome and subclinical atherosclerosis in patients with vitiligo. Seventy patients with nonsegmental vitiligo and 70 age-matched and gender-matched healthy controls participated in the study. These participants were investigated for metabolic syndrome criteria. The mean intima-media thickness of the common carotid artery (MIMT-CCA) of the subjects was measured for assessment of subclinical atherosclerosis. Metabolic syndrome and subclinical atherosclerosis were significantly more frequent in vitiligo patients compared with the controls (P = .006 and P = .002, respectively). In addition, metabolic syndrome and subclinical atherosclerosis had positive, significant correlations with the severity and duration of vitiligo (P = .031 and r = .482; P < .01, respectively). Our study suggested that patients with vitiligo, especially those with more chronic and severe disease or concomitant metabolic syndrome, are at a higher risk of developing cardiovascular diseases. Therefore, early diagnosis and treatment of metabolic syndrome in patients with vitiligo to prevent cardiovascular complications were recommended.
炎症性和自身免疫性皮肤病，如白癜风，可能与全身性疾病有关，包括内分泌和心血管疾病，这是由于发病机制存在一些相似之处。本研究旨在评估白癜风患者的代谢综合征和亚临床动脉粥样硬化。70 例非节段性白癜风患者和 70 名年龄和性别匹配的健康对照者参与了这项研究。对这些参与者进行了代谢综合征标准的调查。为了评估亚临床动脉粥样硬化，测量了受试者颈总动脉内膜中层厚度（MIMT-CCA）。与对照组相比，白癜风患者的代谢综合征和亚临床动脉粥样硬化的发生率显著更高（P =.006 和 P =.002）。此外，代谢综合征和亚临床动脉粥样硬化与白癜风的严重程度和持续时间呈正相关，具有统计学意义（P =.031 和 r =.482；P < .01）。我们的研究表明，白癜风患者，尤其是那些疾病更慢性、更严重或伴有代谢综合征的患者，患心血管疾病的风险更高。因此，建议对白癜风患者进行早期诊断和治疗代谢综合征，以预防心血管并发症。
