Department of Family Medicine, Chungbuk National University Hospital, Cheongju 28644, Korea.
Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Korea.
Nutrients. 2021 Jan 24;13(2):338. doi: 10.3390/nu13020338.
(1) Background: Subclinical inflammation as a risk factor of cardiovascular diseases was clinically measured using C-reactive protein (CRP) level. (2) Methods: This study was cross-sectionally designed based the 2015-2018 Korean National Health and Nutrition Examination Survey (KNHANES). The ratio of daily omega-3 fatty acids to energy intake (ω3FA ratio) was classified into four quartile groups (Q1, <0.3%; Q2, 0.3%-<0.6%; Q3, 0.6%-<1.0%; and Q4, ≥1.0% in both sexes). Logistic regression analysis was conducted to investigate the association between the ω3FA ratio and subclinical inflammation defined as CRP levels ≥3 mg/dL. (3) Results: The ω3FA ratio in subjects without and with subclinical inflammation was 0.8% and 0.7% in men (-value = 0.001), and 0.8% and 0.8% in women (-value = 0.491), respectively. The prevalence of subclinical inflammation in males decreased with increasing quartile of ω3FA ratio (12.9%, 9.6%, 7.4%, and 7.7%, -value = 0.033), while female prevalence was not significant among quartile groups. Compared to Q1, odds ratios (95% confidence intervals) for subclinical inflammation of Q2, Q3, and Q4 were 0.740 (0.465-1.177), 0.564 (0.341-0.930), and 0.549 (0.317-0.953) in males, and 1.066 (0.653-1.741), 1.105 (0.600-1.718), and 0.934 (0.556-1.571) in females after full adjustment. (4) Conclusion: The ω3FA ratio is associated with subclinical inflammation in men.
(1) 背景：亚临床炎症作为心血管疾病的危险因素，临床上使用 C 反应蛋白（CRP）水平进行测量。(2) 方法：本研究基于 2015-2018 年韩国国家健康和营养检查调查（KNHANES）进行了横断面设计。每日ω-3 脂肪酸与能量摄入的比例（ω3FA 比值）分为四个四分位组（Q1，<0.3%；Q2，0.3%-<0.6%；Q3，0.6%-<1.0%；Q4，男女均≥1.0%）。采用 logistic 回归分析探讨了 ω3FA 比值与 CRP 水平≥3mg/dL 定义的亚临床炎症之间的关系。(3) 结果：无亚临床炎症和有亚临床炎症的受试者的 ω3FA 比值分别为男性 0.8%和 0.7%（-值=0.001），女性 0.8%和 0.8%（-值=0.491）。男性亚临床炎症的患病率随着 ω3FA 比值四分位组的升高而降低（12.9%、9.6%、7.4%和 7.7%，-值=0.033），而女性各四分位组之间的患病率无显著性差异。与 Q1 相比，Q2、Q3 和 Q4 亚临床炎症的比值比（95%置信区间）分别为男性 0.740（0.465-1.177）、0.564（0.341-0.930）和 0.549（0.317-0.953），女性为 1.066（0.653-1.741）、1.105（0.600-1.718）和 0.934（0.556-1.571），均经完全调整。(4) 结论：ω3FA 比值与男性的亚临床炎症有关。
