Mulligan Angela A, Hayhoe Richard P G, Luben Robert N, Welch Ailsa A
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridgeshire CB1 8RN, UK.
NIHR BRC Diet, Anthropometry and Physical Activity Group, MRC Epidemiology Unit, University of Cambridge, Cambridgeshire CB2 0AH, UK.
Antioxidants (Basel). 2021 Jan 22;10(2):159. doi: 10.3390/antiox10020159.
The prevalence of sarcopenia, frailty and fractures is increasing. Prevention options are limited, but dietary factors including vitamin E have the potential to confer some protection. This study investigated cross-sectional associations between dietary and plasma concentrations of vitamin E with indices of skeletal muscle mass (SMM) ( = 14,179 and 4283, respectively) and bone density ( = 14,694 and 4457, respectively) and longitudinal fracture risk ( = 25,223 and 7291, respectively) in European Prospective Investigation Into Cancer and Nutrition (EPIC)-Norfolk participants, aged 39-79 years at baseline. Participants completed a health and lifestyle questionnaire, a 7-day diet diary (7dDD) and had anthropometric measurements taken. Fat-free mass (as a SMM proxy) was measured using bioimpedance and bone density was measured using calcaneal broadband ultrasound attenuation (BUA) and incident fractures over 18.5 years of follow-up. Associations between indices of SMM, BUA and fracture risk were investigated by quintiles of dietary vitamin E intake or plasma concentrations. Positive trends in SMM indices and BUA were apparent across dietary quintiles for both sexes, with interquintile differences of 0.88%-1.91% ( < 0.001), and protective trends for total and hip fracture risk. Circulating plasma α- and γ-tocopherol results matched the overall dietary findings. Dietary vitamin E may be important for musculoskeletal health but further investigation is required to fully understand the relationships of plasma tocopherols.
肌肉减少症、衰弱和骨折的患病率正在上升。预防方法有限，但包括维生素E在内的饮食因素有可能提供一定程度的保护。本研究调查了欧洲癌症与营养前瞻性调查（EPIC）-诺福克研究中年龄在39至79岁之间的参与者（基线时）饮食和血浆维生素E浓度与骨骼肌质量（SMM）指标（分别为n = 14,179和4283）、骨密度（分别为n = 14,694和4457）以及纵向骨折风险（分别为n = 25,223和7291）之间的横断面关联。参与者完成了一份健康和生活方式问卷、一份7天饮食日记（7dDD），并进行了人体测量。使用生物电阻抗测量无脂肪质量（作为SMM的替代指标），使用跟骨宽带超声衰减（BUA）测量骨密度，并在18.5年的随访中记录新发骨折情况。通过饮食维生素E摄入量或血浆浓度的五分位数来研究SMM、BUA指标与骨折风险之间的关联。男女两性在饮食五分位数中，SMM指标和BUA均呈现出明显的正向趋势，五分位数间差异为0.88%-1.91%（P < 0.001），并且对总骨折风险和髋部骨折风险呈现出保护趋势。循环血浆α-和γ-生育酚的结果与总体饮食研究结果相符。饮食中的维生素E可能对肌肉骨骼健康很重要，但需要进一步研究以充分了解血浆生育酚之间的关系。
