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卵巢癌患者的生育力保存。

Fertility preservation in ovarian cancer patients.

机构信息

Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Reproductive Medicine Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

出版信息

Gynecol Endocrinol. 2021 Jun;37(6):483-489. doi: 10.1080/09513590.2021.1872534. Epub 2021 Jan 27.

Abstract

Ovarian cancer is more frequent in post-menopausal women, however it can also occur in young premenopausal women. After diagnosis and cancer staging, health care providers should address the possibility of infertility and might offer fertility preservation options. Chemotherapy, frequently used when treating ovarian cancer, has proven to cause extensive ovarian damage. Standard surgery may be aggressive and the recurrence risk may not be relevant enough to opt for these approaches. Fertility sparing surgery has been progressively accepted and many alternative surgical approaches have proven to be successful in both cancer treatment, fertility preservation and low recurrence rates. Though there are several techniques available for fertility preservation in cancer patients, when dealing with ovarian cancer patients, oocyte and embryo cryopreservation are the only suitable. Ovarian tissue cryopreservation has been largely studied, but no data on ovarian cancer patients exist, due to the risk of reimplanting cancer cells.

摘要

卵巢癌在绝经后妇女中更为常见,但也可能发生在年轻的绝经前妇女中。在诊断和癌症分期后,医疗保健提供者应考虑不孕的可能性,并可能提供生育保存选择。化疗常用于治疗卵巢癌,已被证明会导致广泛的卵巢损伤。标准手术可能具有侵袭性,复发风险可能不足以选择这些方法。保留生育能力的手术已逐渐被接受,许多替代手术方法已被证明在癌症治疗、生育力保存和低复发率方面都取得了成功。尽管癌症患者有多种生育力保存技术,但在处理卵巢癌患者时,卵母细胞和胚胎冷冻保存是唯一合适的方法。卵巢组织冷冻保存已得到广泛研究,但由于存在重新植入癌细胞的风险,因此尚无关于卵巢癌患者的数据。

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