Aggarwal Jyoti, Singh Akansha, Gupta Sanjeev, Prasad Rajendra
Department of Biochemistry, MMIMSR, Mullana, Ambala, India.
Department of Dermatology, MMIMSR, Mullana, Ambala, India.
Indian J Clin Biochem. 2021 Jan;36(1):120-123. doi: 10.1007/s12291-019-00870-9. Epub 2020 Jan 1.
Psoriasis is a common and an inflammatory skin disease. Trace elements play an important role in the skin metabolism such as keratinisation and melanin formation as well as immunological and inflammatory reactions. Henceforth, the present study was aimed to evaluate the essential metals with special reference to Cu and Zn. In this study, 72 psoriatic patients and 50 controls were enrolled. On the basis of PASI score psoriatic group comprising of 48 mild and 24 severe psoriatic patients were grouped. The serum trace elements analysis in the subjects revealed that serum Cu levels and Cu/Zn ratio was significantly higher in the psoriatic patients as compared to controls. Interestingly, severity of the psoriasis was well correlated with the serum Cu levels. Taking together, all these findings suggest that Cu may be a major culprit in the pathogenesis as well as in the severity of the disease.
银屑病是一种常见的炎症性皮肤病。微量元素在皮肤代谢中发挥着重要作用，如角质化和黑色素形成以及免疫和炎症反应。因此，本研究旨在评估必需金属，特别是铜和锌。本研究纳入了72例银屑病患者和50例对照。根据银屑病面积和严重程度指数（PASI）评分，将银屑病组分为48例轻度和24例重度银屑病患者。受试者的血清微量元素分析显示，与对照组相比，银屑病患者的血清铜水平和铜/锌比值显著更高。有趣的是，银屑病的严重程度与血清铜水平密切相关。综上所述，所有这些发现表明铜可能是该疾病发病机制以及严重程度的主要罪魁祸首。
