Shahidi-Dadras Mohammad, Namazi Nastaran, Younespour Shima
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.
Indian Dermatol Online J. 2017 Jul-Aug;8(4):250-253. doi: 10.4103/idoj.IDOJ_230_16.
There is a great body of evidence indicating that some inflammatory skin diseases, such as psoriasis, are mediated by oxidative stress. Trace metals have been shown to be involved in oxidative stress response. Altered trace metal homeostasis in psoriasis has been studied. However, limited number of studies has focused on the involvement of metal binding proteins in psoriasis.
In a case control-study, serum levels of Iron (Fe), Copper (Cu), Transferrin (Trf), and Ceruloplasmin (Cp) were measured in 40 psoriasis patients and matched healthy controls. The severity of the disease was measured using psoriasis area and severity index (PASI), and the association of severity based on PASI score and measured elements and proteins was investigated.
Forty patients with psoriasis (mild: 14 and moderate to severe: 26) and 40 healthy controls were included in this study. The serum Fe, Trf, and Cu/Cp levels of the patients with psoriasis were statistically lower compared with those of the controls; serum levels of Cp was elevated in patients with psoriasis compared to controls ( = 0.02). No significant difference was observed between the two groups regarding serum levels of Cu ( = 0.07).
Cu/Cp ratio of the patients with psoriasis was statistically lower compared with those of the controls.
有大量证据表明，一些炎症性皮肤病，如银屑病，是由氧化应激介导的。痕量金属已被证明参与氧化应激反应。银屑病中痕量金属稳态的改变已得到研究。然而，关注金属结合蛋白在银屑病中作用的研究数量有限。
在一项病例对照研究中，测定了40例银屑病患者和相匹配的健康对照者血清中铁（Fe）、铜（Cu）、转铁蛋白（Trf）和铜蓝蛋白（Cp）的水平。使用银屑病面积和严重程度指数（PASI）来衡量疾病的严重程度，并研究基于PASI评分的严重程度与所测元素和蛋白质之间的关联。
本研究纳入了40例银屑病患者（轻度：14例，中度至重度：26例）和40例健康对照者。银屑病患者的血清铁、转铁蛋白和铜/铜蓝蛋白水平与对照组相比有统计学意义的降低；与对照组相比，银屑病患者的血清铜蓝蛋白水平升高（P = 0.02）。两组之间血清铜水平无显著差异（P = 0.07）。
银屑病患者的铜/铜蓝蛋白比值与对照组相比有统计学意义的降低。
