维生素 D、微量元素、糖和脂代谢在银屑病诊断和严重程度评估中的临床价值。
Clinical Value of Vitamin D, Trace Elements, Glucose, and Lipid Metabolism in Diagnosis and Severity Evaluation of Psoriasis.
机构信息
Department of Dermatology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, 213000, China.
The Wujin Clinical College of Xuzhou Medical University, Changzhou, 213000, China.
出版信息
Comput Math Methods Med. 2022 Jul 14;2022:8622435. doi: 10.1155/2022/8622435. eCollection 2022.
OBJECTIVE
The levels of vitamin D, trace elements, and glucose and lipid metabolism in psoriasis were evaluated, and their value in disease diagnosis and severity evaluation was explored.
METHODS
In this study, the serum trace elements, blood glucose, and blood lipid indexes of 360 patients with psoriasis and 500 healthy subjects were compared and analyzed.
RESULTS
The results of 25-(OH) D3, Cu/Zn, and HDL-C in patients with psoriasis were significantly different from those in the control group. With the aggravation of the disease, Psoriasis Area and Severity Index (PASI) was positively correlated with 25-(OH) D3 and HDL-C and negatively correlated with Cu/Zn. The AUC of the three indexes for the diagnosis of psoriasis was 0.899, 0.675, and 0.848, respectively.
CONCLUSION
There are metabolic abnormalities of 25-(OH) D3, Cu/Zn, and HDL-C in patients with psoriasis, and paying attention to these indicators is conducive to the diagnosis of disease.
目的
评估银屑病患者维生素 D、微量元素、葡萄糖和脂代谢水平，探讨其在疾病诊断和严重程度评估中的价值。
方法
本研究比较分析了 360 例银屑病患者和 500 例健康对照者的血清微量元素、血糖、血脂指标。
结果
银屑病患者的 25-(OH)D3、Cu/Zn 和 HDL-C 结果与对照组有显著差异。随着病情的加重，银屑病面积和严重程度指数（PASI）与 25-(OH)D3 和 HDL-C 呈正相关，与 Cu/Zn 呈负相关。这三个指标诊断银屑病的 AUC 分别为 0.899、0.675 和 0.848。
结论
银屑病患者存在 25-(OH)D3、Cu/Zn 和 HDL-C 的代谢异常，关注这些指标有助于疾病的诊断。
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