Xi'an Jiaotong University Health Science Center, Xi'an, China.
Department of Pharmacy, Xi'an Central Hospital, Xi'an, China.
PLoS One. 2021 Jan 28;16(1):e0245670. doi: 10.1371/journal.pone.0245670. eCollection 2021.
Tobacco smoking and alcohol drinking are associated with several diseases, and studies on the joint effects of smoking and drinking are rare.
This study investigates the joint effects of tobacco smoking and alcohol drinking on all-cause and premature mortality in a contemporary cohort.
The China Health and Retirement Longitudinal Study (CHARLS) is an ongoing nationally representative survey of subjects aged over 45 years in China that was performed every two years for a total of three waves from 2011 to 2015 in China. We used weighted logistic regression models to estimate the joint effects of tobacco smoking and alcohol drinking on all-cause and premature mortality.
After adjusting for prespecified confounders, the odds ratios (ORs) of all-cause mortality were 1.51 (95% CI: 1.09-2.10) and 1.47 (95% CI: 1.03-2.08) in smokers and smokers/drinkers, respectively. Compared with nonsmokers/nondrinkers, the OR of smokers/drinkers for premature death was 3.14 (95% CI: 1.56-6.34). In the female subgroup, there was an approximately 5-fold (OR = 4.95; 95% CI: 2.00-12.27) odds of premature mortality for smokers/drinkers compared to nonsmokers/nondrinkers.
This study found a joint effect of tobacco smoking and alcohol drinking on all-cause and premature mortality among a contemporary and nationally representative cohort in China. Our results suggested that the joint effects were more pronounced in women, but further research is needed.
吸烟和饮酒与多种疾病相关，关于吸烟和饮酒联合作用的研究较少。
本研究旨在探讨当代中国人群中吸烟和饮酒联合作用对全因和早逝的影响。
中国健康与养老追踪调查（CHARLS）是一项在中国进行的、针对 45 岁以上人群的全国代表性调查，每两年进行一次，共进行了三波调查，时间为 2011 年至 2015 年。我们使用加权逻辑回归模型来估计吸烟和饮酒联合作用对全因和早逝的影响。
在调整了预设的混杂因素后，吸烟者和吸烟者/饮酒者的全因死亡率的比值比（ORs）分别为 1.51（95%CI：1.09-2.10）和 1.47（95%CI：1.03-2.08）。与非吸烟者/非饮酒者相比，吸烟者/饮酒者的早逝风险的 OR 为 3.14（95%CI：1.56-6.34）。在女性亚组中，吸烟者/饮酒者的早逝风险大约是不吸烟者/不饮酒者的 5 倍（OR=4.95；95%CI：2.00-12.27）。
本研究发现，在中国当代、具有全国代表性的队列中，吸烟和饮酒的联合作用与全因和早逝有关。我们的研究结果表明，这种联合作用在女性中更为明显，但还需要进一步的研究。
