Duan Guo-Fang, Liu Yang, Zhang Li-Na, Li Hong-Ye, Liu Jie-Sheng, Yang Wei-Dong
Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Mar Drugs. 2021 Jan 27;19(2):63. doi: 10.3390/md19020063.
Diarrhetic shellfish toxins (DSTs), some of the most important phycotoxins, are distributed almost all over the world, posing a great threat to human health through the food chain. Therefore, it is of great significance to find effective methods to reduce toxin accumulation in shellfish. In this paper, we observed the effects of four phytochemicals including cinnamaldehyde (CA), quercetin, oridonin and allicin on the accumulation of DSTs in the digestive gland of after exposure to the DSTs-producing . We found that, among the four phytochemicals, CA could effectively decrease the accumulation of DSTs (okadaic acid-eq) in the digestive gland of . Further evidence demonstrated that CA could reduce the histological alterations of the digestive gland of a mussel caused by DSTs. RT-qPCR showed that CA could suppress the CYP3A4 induction by DSTs, suggesting that the DSTs' decrease induced by CA might be related to the inhibition of CYP3A4 transcription induction. However, further studies on the underlying mechanism, optimal treatment time, ecological safety and cost should be addressed before cinnamaldehyde is used to decrease the accumulation of DSTs in field.
腹泻性贝类毒素（DSTs）是一些最重要的藻毒素，几乎分布于世界各地，通过食物链对人类健康构成巨大威胁。因此，找到有效方法减少贝类中毒素积累具有重要意义。在本文中，我们观察了肉桂醛（CA）、槲皮素、冬凌草甲素和大蒜素这四种植物化学物质对暴露于产DSTs的[具体生物名称未给出]后，其消化腺中DSTs积累的影响。我们发现，在这四种植物化学物质中，CA能有效降低[具体生物名称未给出]消化腺中DSTs（以冈田酸当量计）的积累。进一步的证据表明，CA可减轻DSTs对贻贝消化腺造成的组织学改变。RT-qPCR显示，CA可抑制DSTs诱导的CYP3A4表达，这表明CA导致DSTs减少可能与抑制CYP3A4转录诱导有关。然而，在将肉桂醛用于减少野外DSTs积累之前，应进一步研究其潜在机制、最佳处理时间、生态安全性和成本。
