Baiardo Redaelli Martina, Landoni Giovanni, Di Napoli Davide, Morselli Federica, Sartorelli Marianna, Sartini Chiara, Ruggeri Annalisa, Salonia Andrea, Dagna Lorenzo, Zangrillo Alberto
Department of Anesthesia and Intensive Care, IRCCS San Raffaele Hospital, Milan, Italy.
Department of Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Saudi J Med Med Sci. 2021 Jan-Apr;9(1):59-62. doi: 10.4103/sjmms.sjmms_542_20. Epub 2020 Dec 15.
In the first wave of the novel coronavirus (severe acute respiratory syndrome coronavirus 2) infections, Italy experienced a heavy burden of hospital admissions for acute respiratory distress syndromes associated with the novel coronavirus disease (COVID-19). Early evidence suggested that females are less affected than males.
This study aimed to assess the gender-related differences in presentation and severity among COVID-19 patients admitted to IRCCS San Raffaele Hospital, Milan, Italy.
This prospective observational study included all patients admitted to the hospital between February 25 and April 19, 2020, with a positive real-time reverse-transcriptase polymerase chain reaction for COVID-19. The following data were collected: date of admission, gender, age and details of intensive care unit admission and outcomes.
A total of 901 patients with COVID-19 were admitted to the hospital and provided consent for the study. Of these, 284 were female (31.5%). The percentage of admitted female patients significantly increased over time (25.9% of all admissions in the first half of the study period vs. 37.1% in the second half; < 0.001). Females accounted for 14.4% of all COVID-19 intensive care unit admissions. There was no gender-based difference in the overall hospital mortality: 20.1% for females and 19.2% for males ( = 0.8).
In our hospital, which was in the epicenter of the first wave of COVID-19 pandemic in Italy, female patients were few, presented late and were less critical than male patients.
在新型冠状病毒（严重急性呼吸综合征冠状病毒2）感染的第一波疫情中，意大利因新型冠状病毒病（COVID-19）相关的急性呼吸窘迫综合征而入院的患者负担沉重。早期证据表明，女性受影响的程度低于男性。
本研究旨在评估意大利米兰圣拉斐尔医院收治的COVID-19患者在临床表现和严重程度方面的性别差异。
这项前瞻性观察性研究纳入了2020年2月25日至4月19日期间入院且COVID-19实时逆转录聚合酶链反应呈阳性的所有患者。收集了以下数据：入院日期、性别、年龄以及重症监护病房入住情况和结局的详细信息。
共有901例COVID-19患者入院并同意参与本研究。其中，284例为女性（31.5%）。入院女性患者的比例随时间显著增加（研究期上半年所有入院患者的25.9%，下半年为37.1%；<0.001）。女性占所有COVID-19重症监护病房入院患者的14.4%。总体医院死亡率不存在性别差异：女性为20.1%，男性为19.2%（=0.8）。
在我们这家位于意大利第一波COVID-19大流行中心的医院，女性患者较少，就诊较晚，病情也不如男性患者严重。
